AiPD: Autoinhibited Protein Database

Q9Y3C1

Gene name	NOP16 (CGI-117, HSPC111)
Protein name	Nucleolar protein 16
Names	HBV pre-S2 trans-regulated protein 3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51491
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-51 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

11 structures for Q9Y3C1

Entry ID	Method	Resolution	Chain	Position	Source
8FKP	EM	285 A	SZ	1-178	PDB
8FKQ	EM	276 A	SZ	1-178	PDB
8FKR	EM	289 A	SZ	1-178	PDB
8FKS	EM	288 A	SZ	1-178	PDB
8FKT	EM	281 A	SZ	1-178	PDB
8FKU	EM	282 A	SZ	1-178	PDB
8FKV	EM	247 A	SZ	1-178	PDB
8FKW	EM	250 A	SZ	1-178	PDB
8FKX	EM	259 A	SZ	1-178	PDB
8FKY	EM	267 A	SZ	1-178	PDB
AF-Q9Y3C1-F1	Predicted				AlphaFoldDB

152 variants for Q9Y3C1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs768676655 CA3568533	2	P>L		No	ClinGen ExAC gnomAD
CA3568530 rs749169901	3	K>N		No	ClinGen ExAC TOPMed gnomAD
rs777430631 CA3568528	4	A>T		No	ClinGen ExAC gnomAD
rs756120217 CA3568527	5	K>E		No	ClinGen ExAC gnomAD
rs371311461 CA131872955	6	G>D		No	ClinGen ESP TOPMed gnomAD
TCGA novel	8	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1359686985 CA362255835	9	R>W		No	ClinGen gnomAD
CA362255804 rs1222357596	11	Q>*		No	ClinGen gnomAD
CA362255806 rs1222357596	11	Q>E		No	ClinGen gnomAD
CA362255808 rs1222357596	11	Q>K		No	ClinGen gnomAD
rs1026225217 CA131872941	12	K>N		No	ClinGen TOPMed
rs201660459 CA3568524	17	V>D		No	ClinGen 1000Genomes ExAC gnomAD
rs751258265 CA3568523	18	N>H		No	ClinGen ExAC gnomAD
CA3568522 rs765994335	18	N>S		No	ClinGen ExAC gnomAD
CA3568520 rs374285141	24	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA3568518 rs762354832	27	R>G		No	ClinGen ExAC
CA362255655 rs1417035183	28	R>W		No	ClinGen TOPMed gnomAD
TCGA novel	30	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768728192 CA3568516	32	P>R		No	ClinGen ExAC gnomAD
CA3568514 rs775419543	33	R>P		No	ClinGen ExAC gnomAD
rs772408909 CA3568513	35	E>D		No	ClinGen ExAC gnomAD
rs1340496823 CA362255145	39	I>V		No	ClinGen gnomAD
CA3568497 rs35906642	40	R>G		No	ClinGen ExAC gnomAD
CA131872669 rs369167277	43	W>*		No	ClinGen ESP TOPMed
rs772025977 CA3568496	44	D>H		No	ClinGen ExAC TOPMed
CA362255073 rs772025977	44	D>N		No	ClinGen ExAC TOPMed
rs759828112 CA3568495	45	H>Q		No	ClinGen ExAC gnomAD
CA131872648 rs200947536	46	A>T		No	ClinGen Ensembl
CA3568494 rs761435181	48	S>*		No	ClinGen ExAC TOPMed gnomAD
rs769713350 CA3568493	49	V>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	50	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201019782 CA3568492	51	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1470225702 CA362254944	54	A>P		No	ClinGen gnomAD
rs768780614 CA3568490	59	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA362254876 rs1167631598	62	P>S		No	ClinGen gnomAD
CA362254855 rs369903036	64	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs369903036 CA3568489	64	R>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA3568488 rs376625530	65	A>V		No	ClinGen ESP ExAC gnomAD
CA362254840 rs1350415891	66	V>E		No	ClinGen gnomAD
CA3568486 rs750097354	68	L>F		No	ClinGen ExAC gnomAD
rs1204787616 CA362254823	68	L>H		No	ClinGen TOPMed gnomAD
CA3568487 rs750097354	68	L>V		No	ClinGen ExAC gnomAD
rs1260922329 CA362254819	69	R>C		No	ClinGen TOPMed
rs372260739 CA362254818	69	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs372260739 CA3568485	69	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs372260739 CA362254817	69	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA362254812 rs1484739968	70	K>R		No	ClinGen TOPMed
rs754267917 CA3568483	71	R>G		No	ClinGen ExAC gnomAD
rs760330393 CA3568450	73	V>G		No	ClinGen ExAC gnomAD
CA362254781 rs1271852355	73	V>M		No	ClinGen TOPMed
rs1011453221 CA362254771	74	K>N		No	ClinGen gnomAD
rs771970692 CA3568448	75	A>G		No	ClinGen ExAC TOPMed gnomAD
rs775343536 CA3568449	75	A>T		No	ClinGen ExAC gnomAD
CA362254766 rs771970692	75	A>V		No	ClinGen ExAC TOPMed gnomAD
CA362254746 rs1271196300	78	V>L		No	ClinGen TOPMed
rs770383955 CA3568445	80	I>K		No	ClinGen ExAC TOPMed gnomAD
CA3568443 rs777343793	81	E>A		No	ClinGen ExAC gnomAD
rs748973633 CA3568444	81	E>K		No	ClinGen ExAC gnomAD
CA362254722 rs1398857598	82	E>*		No	ClinGen Ensembl
CA3568442 rs756512349	83	R>G		No	ClinGen ExAC gnomAD
CA131871264 rs748516531	83	R>K		No	ClinGen ExAC TOPMed gnomAD
rs748516531 CA3568441	83	R>T		No	ClinGen ExAC TOPMed gnomAD
rs1227260064 CA362254703	85	K>E		No	ClinGen gnomAD
rs1227260064 CA362254704	85	K>Q		No	ClinGen gnomAD
CA3568440 rs781612471	88	V>I		No	ClinGen ExAC gnomAD
CA362254675 rs1429153685	89	R>Q		No	ClinGen TOPMed gnomAD
CA362254676 rs752090377	89	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	92	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3568437 rs780301628	94	L>P		No	ClinGen ExAC TOPMed gnomAD
CA362254421 rs1310965446	98	E>D		No	ClinGen TOPMed gnomAD
CA3568404 rs761394555	98	E>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	99	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3568403 rs776304308	100	E>*		No	ClinGen ExAC TOPMed gnomAD
CA362254414 rs776304308	100	E>K		No	ClinGen ExAC TOPMed gnomAD
CA362254402 rs1215551465	101	A>G		No	ClinGen gnomAD
rs1013152581 CA362254367	106	K>N		No	ClinGen TOPMed gnomAD
CA362254339 rs1561781742	110	T>S		No	ClinGen Ensembl
TCGA novel	112	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768904952 CA362254324	113	R>L		No	ClinGen ExAC TOPMed gnomAD
rs768904952 CA3568401	113	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA362254325 rs1468526131	113	R>W	Variant assessed as Somatic; 4.638e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs747437624 CA3568400	114	D>G		No	ClinGen ExAC gnomAD
rs780563268 CA3568399	116	I>T		No	ClinGen ExAC TOPMed gnomAD
CA362254307 rs1490053833	116	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA3568398 rs772746797	118	Y>C		No	ClinGen ExAC
CA362254288 rs1321988014	119	V>I		No	ClinGen gnomAD
rs35916027 CA3568397	120	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3568396 rs778885926	120	R>H		No	ClinGen ExAC TOPMed gnomAD
rs550414913 CA131870401	122	M>L		No	ClinGen 1000Genomes
rs757323676 CA3568395	124	E>G		No	ClinGen ExAC TOPMed gnomAD
rs749478336 CA3568394	125	N>T		No	ClinGen ExAC gnomAD
rs777997362 CA3568393	126	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA3568390 CA3568391 rs766126221	127	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	128	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA362254217 rs1332944885	129	D>E		No	ClinGen TOPMed
rs564105798 CA3568387	130	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs531236625 CA3568389	130	Y>N		No	ClinGen 1000Genomes ExAC gnomAD
rs564105798 CA3568388	130	Y>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1292266651 CA362253889	132	A>D		No	ClinGen TOPMed
rs752413462 CA3568341	134	A>T		No	ClinGen ExAC gnomAD
CA3568340 rs767341425	134	A>V		No	ClinGen ExAC gnomAD
rs759109610 CA3568339	135	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA3568338 rs751991573	135	R>H		No	ClinGen ExAC gnomAD
rs201464061 CA3568337	136	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1332463491 CA362253833	136	D>Y		No	ClinGen TOPMed
rs1167787140 CA362253793	138	K>N		No	ClinGen gnomAD
rs763535412 CA3568336	139	N>Y		No	ClinGen ExAC gnomAD
rs1443198030 CA362253755	141	Y>C		No	ClinGen gnomAD
CA3568333 rs769866161	142	Q>*		No	ClinGen ExAC gnomAD
rs1201501127 CA362253738	142	Q>H		No	ClinGen gnomAD
rs11556383 CA131869663	142	Q>P		No	ClinGen TOPMed
CA362253727 rs1480617288	143	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs761822995 CA3568332	144	T>N		No	ClinGen ExAC gnomAD
rs768963656 CA3568330	146	K>R		No	ClinGen ExAC TOPMed gnomAD
CA362253669 rs1187168709	147	Q>R		No	ClinGen TOPMed
rs1255635175 CA362253653	148	I>M		No	ClinGen TOPMed
rs747177509 CA3568329	148	I>T		No	ClinGen ExAC gnomAD
CA3568328 rs778792802	149	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA131869629 rs200749495	149	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA TOPMed gnomAD
CA362253607 rs1314670444	152	I>M		No	ClinGen gnomAD
CA131869624 rs994865659	154	V>I		No	ClinGen TOPMed gnomAD
CA362253587 rs1431107056	155	Y>C		No	ClinGen TOPMed gnomAD
CA3568325 rs374004308	155	Y>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA3568326 rs374004308	155	Y>N		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	156	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3568323 rs369844270	157	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs535942388 CA3568322	157	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA3568324 rs369844270	157	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1442444633 CA362253565	158	F>V		No	ClinGen gnomAD
CA131869573 rs967264894	159	Y>C		No	ClinGen TOPMed
TCGA novel	159	Y>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3568321 rs751121017	160	P>L		No	ClinGen ExAC TOPMed gnomAD
rs751121017 CA3568320	160	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs1418994963 CA362253543	161	A>P		No	ClinGen gnomAD
rs1581403349 CA362253532	162	E>A		No	ClinGen Ensembl
CA131869542 rs987270358	163	W>*		No	ClinGen TOPMed gnomAD
CA3568316 rs765792065	165	D>E		No	ClinGen ExAC TOPMed gnomAD
CA3568317 rs750939447	165	D>N		No	ClinGen ExAC TOPMed gnomAD
rs781413892 CA131869526	167	L>F		No	ClinGen TOPMed gnomAD
rs776742412 CA3568314	168	D>N		No	ClinGen ExAC gnomAD
rs764031980 CA3568313	169	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs574974181 CA3568312	170	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs775509663 CA3568311	171	Q>H		No	ClinGen ExAC gnomAD
CA3568310 rs556727834	172	K>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs144915498 CA3568309	173	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3568308 rs570834002	174	K>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769896171 CA3568307	175	M>T		No	ClinGen ExAC TOPMed gnomAD
rs374069039 CA131869445	175	M>V		No	ClinGen ESP
CA3568306 rs748073250	176	E>D		No	ClinGen ExAC
rs1561780115 CA362253413	177	V>G		No	ClinGen Ensembl
TCGA novel	178	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1477959866 CA362253407	178	E>K		No	ClinGen TOPMed

No associated diseases with Q9Y3C1

No regional properties for Q9Y3C1

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9Y3C1

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

1 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name	Definition
ribosomal large subunit biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MPKAKGKTRR	QKFGYSVNRK	RLNRNARRKA	APRIECSHIR	HAWDHAKSVR	QNLAEMGLAV
70	80	90	100	110	120
DPNRAVPLRK	RKVKAMEVDI	EERPKELVRK	PYVLNDLEAE	ASLPEKKGNT	LSRDLIDYVR
130	140	150	160	170
YMVENHGEDY	KAMARDEKNY	YQDTPKQIRS	KINVYKRFYP	AEWQDFLDSL	QKRKMEVE