Q9Y1J3

PR
Gene name
pdk-1 (H42K12.1)
Protein name
3-phosphoinositide-dependent protein kinase 1
Names
EC 2.7.11.1 , Pdk-class protein kinase 1
Species
Rattus norvegicus (Rat)
KEGG Pathway
cel:CELE_H42K12.1
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

482-573 (PH domain) SS

Target domain

69-364 (Protein kinase domain)

Relief mechanism

PTM, Ligand binding

Assay

Accessory elements

214-224 (Activation loop from InterPro)

Target domain

69-364 (Protein kinase domain)

Relief mechanism

Assay

267-275 (Activation loop from InterPro)

Target domain

69-364 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9Y1J3

Entry ID Method Resolution Chain Position Source
AF-Q9Y1J3-F1 Predicted AlphaFoldDB

No variants for Q9Y1J3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9Y1J3

No associated diseases with Q9Y1J3

1 regional properties for Q9Y1J3

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 16 - 167 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions

8 GO annotations of biological process

Name Definition
cellular response to metal ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
cellular response to reactive oxygen species Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
dauer larval development The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
learning or memory The acquisition and processing of information and/or the storage and retrieval of this information over time.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
regulation of chemotaxis Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
regulation of synaptic assembly at neuromuscular junction Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q03407 PKH1 Serine/threonine-protein kinase PKH1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9W0V1 Pdk1 3-phosphoinositide-dependent protein kinase 1 Drosophila melanogaster (Fruit fly) SS
O15530 PDPK1 3-phosphoinositide-dependent protein kinase 1 Homo sapiens (Human) EV
Q6A1A2 PDPK2P Putative 3-phosphoinositide-dependent protein kinase 2 Homo sapiens (Human) PR
Q9Z2A0 Pdpk1 3-phosphoinositide-dependent protein kinase 1 Mus musculus (Mouse) SS
O55173 Pdpk1 3-phosphoinositide-dependent protein kinase 1 Rattus norvegicus (Rat) SS
Q19266 pkc-3 Protein kinase C-like 3 Caenorhabditis elegans SS
P34722 tpa-1 Protein kinase C-like 1 Caenorhabditis elegans PR
P90980 pkc-2 Protein kinase C-like 2 Caenorhabditis elegans SS
Q9XTG7 akt-2 Serine/threonine-protein kinase akt-2 Caenorhabditis elegans SS
Q17941 akt-1 Serine/threonine-protein kinase akt-1 Caenorhabditis elegans PR
Q2L6W9 sax-1 Serine/threonine-protein kinase sax-1 Caenorhabditis elegans SS
Q4V3C8 PDPK2 3-phosphoinositide-dependent protein kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MYHNSSQKRH WTFASEEQLA RLRADANRKF KCKAVANGKV LPNDPLFLEP HEEMTLCKYY
70 80 90 100 110 120
EKRLLEFCSV FKPAMPRSVV GTACMYFKRF YLNNSVMEYH PRIIMLTCAF LACKVDEFNV
130 140 150 160 170 180
SSPQFVGNLR ESPLGQEKAL EQILEYELLL IQQLNFHLIV HNPYRPFEGF LIDIKTRYPM
190 200 210 220 230 240
LENPEILRKT ADDFLSRIAL TDAYLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE
250 260 270 280 290 300
NRTCLSQLLD IMKSMRNLVK KYEPPRSEEV AILKQKLERC HSSDLALNMV TKKRKGYEDD
310 320
DYVSKKPKQE EEEWTDDDLV DAL