Q9XTW2

PR
Gene name
famk-1
Protein name
Extracellular serine/threonine protein kinase CeFam20
Names
CeFam20, Golgi casein kinase, Golgi-enriched fraction casein kinase, GEF-CK
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_H03A11.1
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

459-512 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

387-409 (Activation loop from InterPro)

Target domain

248-485 (FAM20, C-terminal)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

3 structures for Q9XTW2

Entry ID Method Resolution Chain Position Source
4KQA X-ray 260 A A/B/C/D 60-512 PDB
4KQB X-ray 304 A A/B 60-512 PDB
AF-Q9XTW2-F1 Predicted AlphaFoldDB

No variants for Q9XTW2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9XTW2

No associated diseases with Q9XTW2

2 regional properties for Q9XTW2

Type Name Position InterPro Accession
domain Homeobox domain 186 - 250 IPR001356
domain Homeobox protein SIX1, N-terminal SD domain 69 - 183 IPR031701

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass type II membrane protein
  • Secreted
  • Resides in the Golgi apparatus membrane and is secreted following propeptide cleavage
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
manganese ion binding Binding to a manganese ion (Mn).
phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IXL6 FAM20C Extracellular serine/threonine protein kinase FAM20C Homo sapiens (Human) PR
10 20 30 40 50 60
MRCNIKRLFT LAIGVFAATL VIISFSKDNY EREWKQGPQS NEARAVGHQS PDLFPVGQNS
70 80 90 100 110 120
LPHQPIPPSL GEKDLSDPFN FLFSSNKITL RKLYDLTKNV DFDQLRQNEC KKNITLSKFW
130 140 150 160 170 180
EKSEQRNVPE DDNWERFYSN IGSCSVYSDD QMIDNLLHDL NTSPIKHVHI MDGGTQVKFV
190 200 210 220 230 240
FTFKNDKQAV FKPMRFGRDY ESDPNHFYFS DFERHHAEIA TFHLDRVLGF RRAIPTVGRV
250 260 270 280 290 300
LNMTTELFEK AEKKLKKTFF FSPAKNFCFV SRCDYYCDTT HAICGLPDMK EGSVQVFLPD
310 320 330 340 350 360
ESAVPRKHNR SPYRRTYSKK NQVAEWQSSM NYCTDKVKTK RQYAHGRRLL DLVDIHILDY
370 380 390 400 410 420
LIGNQDRHHF ESFNVFNDLP SYAIHLDHGR AFGRSDFDDD DIILPLRQCC ILRPSTFQTL
430 440 450 460 470 480
MNFYSTPKSL TKALHESLSK DPAHPILAYK HYPAMERRLA KIMSHILECF ESRGVAEVLV
490 500 510
AEYNNPDVSD AEQNDEEQSE EHQDKKDDKK TV