Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9XT57
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9XT57-F1 | Predicted | AlphaFoldDB |
No variants for Q9XT57
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9XT57 | |||||
No associated diseases with Q9XT57
1 regional properties for Q9XT57
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 54 - 346 | IPR017452 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| beta-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. |
| beta3-adrenergic receptor activity | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of adenylate cyclase activity | Any process that initiates the activity of the inactive enzyme adenylate cyclase. |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP). |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPWPPRNSS | LTPWPDIPTL | APNTANASGL | PGVPWAVALA | GALLALAVLA | IVGGNLLVIV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AIARTPRLQT | MTNVFVTSLA | TADLVVGLLV | VPPGATLALT | GHWPLGVTGC | ELWTSVDVLC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VTASIETLCA | LAVDRYLAVT | NPLRYGALVT | KRRARAAVVL | VWVVSAAVSF | APIMSKWWRV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GADAEAQRCH | SNPRCCTFAS | NMPYALLSSS | VSFYLPLLVM | LFVYARVFVV | ATRQLRLLRR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ELGRFPPEES | PPAPSRSGSP | GPAGPYASPA | GVPSYGRRPA | RLLPLREHRA | LRTLGLIMGT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FTLCWLPFFV | VNVVRALGGP | SLVSGPTFLA | LNWLGYANSA | FNPLIYCRSP | DFQSAFRRLL |
| 370 | 380 | 390 | 400 | ||
| CRCRPEEHLA | AASPPRAPSG | APRVLTSPAG | PRQPSPLDGA | SCGLS |