Q9XSZ4

PR
Gene name
SLC4A4 (NBC1, NBCE1)
Protein name
Electrogenic sodium bicarbonate cotransporter 1
Names
Sodium bicarbonate cotransporter, Na(+)/HCO3(-) cotransporter, Solute carrier family 4 member 4
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100008727
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

12-107 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9XSZ4

Entry ID Method Resolution Chain Position Source
AF-Q9XSZ4-F1 Predicted AlphaFoldDB

No variants for Q9XSZ4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9XSZ4

No associated diseases with Q9XSZ4

2 regional properties for Q9XSZ4

Type Name Position InterPro Accession
domain Bicarbonate transporter-like, transmembrane domain 441 - 956 IPR011531
domain Band 3 cytoplasmic domain 138 - 387 IPR013769

Functions

Description
EC Number
Subcellular Localization
  • Basolateral cell membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
sodium:bicarbonate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in).
solute:inorganic anion antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out).

1 GO annotations of biological process

Name Definition
sodium ion transport The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEDEAVLDRG ASFLKHVCDE EEVEGHHTIY IGVHVPKSYR RRRRHKRKTG HKEKREKERI
70 80 90 100 110 120
SENYSDKSDV ENADESSSSI LKPLISPAAE RIRFILGEED DSPAPPQLFT ELDELLAVDG
130 140 150 160 170 180
QEMEWKETAR WIKFEEKVEQ GGERWSKPHV ATLSLHSLFE LRTCMEKGSI MLDREATSLP
190 200 210 220 230 240
QLVEMIVDHQ IETGLLKPDL KDKVTYTLLR KHRHQTKKSN LRSLADIGKT VSSASRMFTS
250 260 270 280 290 300
PDNGSPAMTH RNLTSSSLND ISDKPEKDQL KNKFMKKLPR DAEASNVLVG EVDFLDTPFI
310 320 330 340 350 360
AFVRLQQAVM LGALTEVPVP TRFLFILLGP KGKAKSYHEI GRAIATLMSD EVFHDIAYKA
370 380 390 400 410 420
KDRHDLIAGI DEFLDEVIVL PPGEWDPAIR IEPPKSLPSS DKRKNMYSGG ENVQMNGDTP
430 440 450 460 470 480
HDGGHGGGGH ADCEELQRTG RFCGGLIKDL KRKAPFFASD FYDALNIQSL SAILFIYLAT
490 500 510 520 530 540
VTNAITFGGL LGDATDNMQG VLESFLGTAV SGAIFCLFAG QPLTILSSTG PVLVFERLLF
550 560 570 580 590 600
NFSKDHNFDY LEFRLWIGLW SAFLCLILVA TDASFLVQYF TRFTEEGFSS LISFIFIYDA
610 620 630 640 650 660
FKKMIKLADY YPINSDFKVG YNTFFSCACV PPDPVNISIA NDTTPAPQEL SAVSSTDMHQ
670 680 690 700 710 720
NATFDWAFLS KKECLRYGGK LVGNNCNFVP DVTLMSFILF LGTYTSSMAL KKFKTSRYFP
730 740 750 760 770 780
TTARKLISDF AIILSILIFC VIDALVGVDT PKLIVPSEFK PTSPNRGWFV PPFGGNPWWV
790 800 810 820 830 840
YLAAAIPALL VTILIFMDQQ ITAVIVNRKE HKLKKGAGYH LDLFWVAILM VVCSFMALPW
850 860 870 880 890 900
YVAATVISIA HIDSLKMETE TSAPGEQPKF LGVREQRVTG TLVFILTGLS VFMAPILKFI
910 920 930 940 950 960
PMPVLYGVFL YMGVASLNGV QFMDRLKLLL MPLKHQPDFI YLRHVPLRRV HLFTFLQVLC
970 980 990 1000 1010 1020
LALLWILKST VAAIIFPVMI LALVAVRKGM DYLFSQHDLS FLDDVIPEKD KKKKEDEKKK
1030 1040 1050 1060 1070
KKKKGSLDSD NDDSDCPYSE KVPSIKIPMD IMEQQPFLSE SKPSDREKSS TFLERHTSC