AiPD: Autoinhibited Protein Database

Gene name	DXR (ISPC, PDE129, At5g62790, MQB2.11)
Protein name	1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic
Names	1-deoxyxylulose-5-phosphate reductoisomerase, DXP reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase, Protein PIGMENT-DEFECTIVE EMBRYO 129
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT5G62790
EC number	1.1.1.267: With NAD(+) or NADP(+) as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-113 (Predicted disordered autoinhibitory region) PR

1-113 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9XFS9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_5_25217288_A_C	2	M>R	No	1000Genomes
ENSVATH00748459	7	L>I	No	1000Genomes
tmp_5_25216988_T_A	37	R>W	No	1000Genomes
ENSVATH03466138	39	N>D	No	1000Genomes
ENSVATH12910535	47	G>D	No	1000Genomes
ENSVATH00748454	78	D>N	No	1000Genomes
ENSVATH12910524	80	P>T	No	1000Genomes
ENSVATH12910509	143	E>G	No	1000Genomes
ENSVATH07469953	153	Y>S	No	1000Genomes
ENSVATH00748442	155	L>P	No	1000Genomes
ENSVATH03466118	162	Q>L	No	1000Genomes
tmp_5_25216127_T_A	172	E>D	No	1000Genomes
ENSVATH14646080	184	A>V	No	1000Genomes
tmp_5_25215968_C_T	194	E>K	No	1000Genomes
ENSVATH07469945	261	D>Y	No	1000Genomes
tmp_5_25215534_C_A	268	K>N	No	1000Genomes
ENSVATH07469941	332	Q>E	No	1000Genomes
tmp_5_25214707_C_A	390	M>I	No	1000Genomes
ENSVATH07469932	440	R>Q	No	1000Genomes
tmp_5_25214401_G_A	464	A>V	No	1000Genomes
ENSVATH00748423	465	N>D	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal	83 - 211	IPR013512
domain	1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal	225 - 308	IPR013644
domain	DXP reductoisomerase C-terminal domain	340 - 461	IPR026877

		Description
EC Number	1.1.1.267	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	Plastid, chloroplast stroma
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chloroplast stroma	The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.

Name	Definition
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH.
manganese ion binding	Binding to a manganese ion (Mn).
NADPH binding	Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.

Name	Definition
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process	The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway that contributes to terpenoid biosynthesis. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins