Q9XEA0
PR
Gene name |
EMB2369 |
Protein name |
Leucine--tRNA ligase, chloroplastic/mitochondrial |
Names |
Leucyl-tRNA synthetase, LeuRS, Protein EMBRYO DEFECTIVE 2369 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G04350 |
EC number |
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9XEA0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9XEA0-F1 | Predicted | AlphaFoldDB |
114 variants for Q9XEA0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH06462308 | 4 | H>Q | No | 1000Genomes | |
| ENSVATH13927773 | 8 | L>F | No | 1000Genomes | |
| tmp_4_2128174_G_A | 16 | V>I | No | 1000Genomes | |
| ENSVATH06462309 | 19 | H>Q | No | 1000Genomes | |
| tmp_4_2128187_G_A | 20 | C>Y | No | 1000Genomes | |
| ENSVATH00461769 | 22 | R>H | No | 1000Genomes | |
| tmp_4_2128219_A_T | 31 | T>S | No | 1000Genomes | |
| ENSVATH00461770 | 38 | Q>R | No | 1000Genomes | |
| ENSVATH02650435 | 39 | P>S | No | 1000Genomes | |
| ENSVATH00461771 | 40 | F>I | No | 1000Genomes | |
| tmp_4_2128249_T_C | 41 | S>P | No | 1000Genomes | |
| ENSVATH10700114 | 51 | Y>F | No | 1000Genomes | |
| ENSVATH02650436 | 56 | R>G | No | 1000Genomes | |
| ENSVATH02650437 | 56 | R>M | No | 1000Genomes | |
| tmp_4_2128306_A_T | 60 | T>S | No | 1000Genomes | |
| tmp_4_2128310_A_G | 61 | E>G | No | 1000Genomes | |
| ENSVATH02650439 | 62 | T>A | No | 1000Genomes | |
| tmp_4_2128313_C_G | 62 | T>S | No | 1000Genomes | |
| tmp_4_2128316_A_G | 63 | H>R | No | 1000Genomes | |
| ENSVATH02650441 | 64 | G>S | No | 1000Genomes | |
| ENSVATH06462310 | 65 | S>N | No | 1000Genomes | |
| ENSVATH09521940 | 67 | K>E | No | 1000Genomes | |
| ENSVATH10700145 | 67 | K>R | No | 1000Genomes | |
| ENSVATH02650442 | 68 | E>K | No | 1000Genomes | |
| tmp_4_2128339_G_A | 71 | V>M | No | 1000Genomes | |
| ENSVATH09521942 | 73 | E>Q | No | 1000Genomes | |
| tmp_4_2128352_C_A | 75 | A>E | No | 1000Genomes | |
| ENSVATH06462312 | 79 | I>M | No | 1000Genomes | |
| ENSVATH06462313 | 82 | K>N | No | 1000Genomes | |
| ENSVATH06462314 | 89 | E>Q | No | 1000Genomes | |
| ENSVATH00461772 | 103 | I>T | No | 1000Genomes | |
| ENSVATH10700146 | 113 | S>A | No | 1000Genomes | |
| ENSVATH06462329 | 206 | R>H | No | 1000Genomes | |
| ENSVATH00461776 | 229 | K>R | No | 1000Genomes | |
| ENSVATH06462332 | 243 | P>A | No | 1000Genomes | |
| tmp_4_2129555_C_G | 264 | H>Q | No | 1000Genomes | |
| ENSVATH02650488 | 265 | P>L | No | 1000Genomes | |
| tmp_4_2129556_C_T | 265 | P>S | No | 1000Genomes | |
| tmp_4_2129758_G_C | 293 | E>D | No | 1000Genomes | |
| ENSVATH02650491 | 310 | E>K | No | 1000Genomes | |
| ENSVATH06462336 | 322 | E>D | No | 1000Genomes | |
| tmp_4_2129843_G_A | 322 | E>K | No | 1000Genomes | |
| ENSVATH02650494 | 353 | Q>H | No | 1000Genomes | |
| ENSVATH10700220 | 362 | E>A | No | 1000Genomes | |
| ENSVATH02650495 | 363 | Q>E | No | 1000Genomes | |
| tmp_4_2130058_G_T | 365 | Q>H | No | 1000Genomes | |
| tmp_4_2130169_G_C | 378 | S>T | No | 1000Genomes | |
| ENSVATH13927847 | 385 | L>F | No | 1000Genomes | |
| tmp_4_2130210_G_A | 392 | V>I | No | 1000Genomes | |
| ENSVATH02650500 | 396 | C>Y | No | 1000Genomes | |
| ENSVATH10700221 | 415 | V>I | No | 1000Genomes | |
| tmp_4_2130386_G_A | 425 | M>I | No | 1000Genomes | |
| tmp_4_2130448_A_T | 446 | K>M | No | 1000Genomes | |
| ENSVATH06462347 | 464 | P>L | No | 1000Genomes | |
| tmp_4_2130501_C_T | 464 | P>S | No | 1000Genomes | |
| tmp_4_2130504_G_C | 465 | G>R | No | 1000Genomes | |
| ENSVATH06462348 | 469 | I>S | No | 1000Genomes | |
| tmp_4_2130521_A_T | 470 | E>D | No | 1000Genomes | |
| ENSVATH00461786 | 474 | T>S | No | 1000Genomes | |
| ENSVATH02650506 | 485 | S>F | No | 1000Genomes | |
| ENSVATH02650507 | 488 | E>D | No | 1000Genomes | |
| tmp_4_2130596_A_T | 495 | E>D | No | 1000Genomes | |
| tmp_4_2130594_G_A | 495 | E>K | No | 1000Genomes | |
| tmp_4_2130783_G_A | 533 | E>K | No | 1000Genomes | |
| tmp_4_2130814_C_T | 543 | S>F | No | 1000Genomes | |
| ENSVATH02650510 | 558 | T>S | No | 1000Genomes | |
| ENSVATH06462354 | 573 | N>K | No | 1000Genomes | |
| ENSVATH06462355 | 579 | T>I | No | 1000Genomes | |
| tmp_4_2131005_G_A | 580 | G>E | No | 1000Genomes | |
| ENSVATH00461787 | 580 | G>R | No | 1000Genomes | |
| tmp_4_2131020_G_A | 585 | R>K | No | 1000Genomes | |
| tmp_4_2131754_G_A | 682 | E>K | No | 1000Genomes | |
| tmp_4_2131772_G_C | 688 | A>P | No | 1000Genomes | |
| ENSVATH10700273 | 693 | R>L | No | 1000Genomes | |
| tmp_4_2131792_A_C | 694 | L>F | No | 1000Genomes | |
| tmp_4_2131812_C_T | 701 | T>I | No | 1000Genomes | |
| ENSVATH10700274 | 702 | I>V | No | 1000Genomes | |
| ENSVATH06462373 | 703 | P>L | No | 1000Genomes | |
| tmp_4_2131824_A_T | 705 | E>V | No | 1000Genomes | |
| ENSVATH06462375 | 722 | I>F | No | 1000Genomes | |
| ENSVATH10700307 | 728 | V>F | No | 1000Genomes | |
| ENSVATH10700308 | 747 | E>G | No | 1000Genomes | |
| tmp_4_2132163_C_G | 765 | D>E | No | 1000Genomes | |
| tmp_4_2132236_G_T | 790 | G>C | No | 1000Genomes | |
| ENSVATH00461795 | 792 | P>S | No | 1000Genomes | |
| tmp_4_2132246_A_C | 793 | Q>P | No | 1000Genomes | |
| ENSVATH10700310 | 794 | S>A | No | 1000Genomes | |
| ENSVATH13927853 | 804 | V>E | No | 1000Genomes | |
| ENSVATH06462381 | 806 | D>N | No | 1000Genomes | |
| ENSVATH06462382 | 809 | P>L | No | 1000Genomes | |
| ENSVATH10700311 | 815 | R>Q | No | 1000Genomes | |
| ENSVATH06462383 | 818 | H>Y | No | 1000Genomes | |
| tmp_4_2132478_C_T | 846 | A>V | No | 1000Genomes | |
| ENSVATH00461798 | 858 | I>T | No | 1000Genomes | |
| tmp_4_2132607_G_C | 859 | E>D | No | 1000Genomes | |
| tmp_4_2132692_T_A | 888 | Y>N | No | 1000Genomes | |
| ENSVATH06462386 | 894 | A>V | No | 1000Genomes | |
| ENSVATH13927895 | 895 | N>S | No | 1000Genomes | |
| ENSVATH06462387 | 896 | P>L | No | 1000Genomes | |
| ENSVATH06462387 | 896 | P>Q | No | 1000Genomes | |
| tmp_4_2132794_C_A | 896 | P>T | No | 1000Genomes | |
| ENSVATH06462389 | 927 | D>A | No | 1000Genomes | |
| ENSVATH06462390 | 929 | A>S | No | 1000Genomes | |
| tmp_4_2132894_C_T | 929 | A>V | No | 1000Genomes | |
| ENSVATH00461802 | 930 | F>I | No | 1000Genomes | |
| ENSVATH10700337 | 931 | V>D | No | 1000Genomes | |
| ENSVATH06462391 | 935 | Q>K | No | 1000Genomes | |
| ENSVATH13927897 | 936 | D>N | No | 1000Genomes | |
| ENSVATH02650524 | 937 | D>G | No | 1000Genomes | |
| ENSVATH10700338 | 948 | I>V | No | 1000Genomes | |
| ENSVATH00461803 | 965 | R>Q | No | 1000Genomes | |
| ENSVATH06462393 | 968 | V>A | No | 1000Genomes | |
| tmp_4_2133010_G_A | 968 | V>I | No | 1000Genomes | |
| tmp_4_2133023_C_G | 972 | T>R | No | 1000Genomes |
No associated diseases with Q9XEA0
5 regional properties for Q9XEA0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aminoacyl-tRNA synthetase, class I, conserved site | 126 - 136 | IPR001412 |
| domain | Aminoacyl-tRNA synthetase, class Ia | 730 - 757 | IPR002300 |
| domain | Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding | 814 - 921 | IPR013155 |
| domain | Methionyl/Leucyl tRNA synthetase | 122 - 254 | IPR015413 |
| domain | Leucyl-tRNA synthetase, editing domain | 303 - 493 | IPR025709 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.4 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aminoacyl-tRNA editing activity | The hydrolysis of an incorrectly aminoacylated tRNA. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| leucine-tRNA ligase activity | Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| embryo development ending in seed dormancy | The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana. |
| leucyl-tRNA aminoacylation | The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q15031 | LARS2 | Leucine--tRNA ligase, mitochondrial | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSHHQILQI | RSDPFVLSHC | CRHTRLTSSL | TLQSPLKQPF | SCLPFRWRRS | YRGGVRSSTT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ETHGSKKEAL | VSETATTSIE | LKRVYPFHEI | EPKWQRYWED | NRIFRTPDDV | DTSKPKFYVL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DMFPYPSGAG | LHVGHPLGYT | ATDILARLRR | MQGYNVLHPM | GWDAFGLPAE | QYAIETGTHP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KTTTLKNIDR | FRLQLKSLGF | SYDWDRELST | TEPDYYKWTQ | WIFLQLYKKG | LAYQAEVPVN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WCPALGTVLA | NEEVVDGVSE | RGGHPVIRKP | MRQWMLKITA | YADRLLEDLD | ELEWPESIKE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MQRNWIGRSE | GAELNFSILD | GEGRETDKEI | TVYTTRPDTL | FGATYMVVAP | EHQLLSYFVT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AEQKQQVEEY | KDFASRKSDL | ERTELQKDKT | GVFTGCYAKN | PANGDAIPIW | VADYVLASYG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TGAIMAVPAH | DTRDNEFALK | YNIPIKWVVR | NEANSSDDAK | QVYPGLGIIE | NSSTLETGLD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| INQLSSKEAA | LKVIEWAERT | GNGKKKVNYK | LRDWLFARQR | YWGEPIPILI | LDESGETIAI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SESELPLTLP | ELNDFTPTGT | GEPPLSKAVS | WVNTVDPSTG | KPAKRETSTM | PQWAGSCWYY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LRFMDPKNPE | ALVDKEKEKY | WSPVDVYVGG | AEHAVLHLLY | SRFWHKVLYD | IGVVSTKEPF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KCVINQGIIL | GEVQYTAWKD | QEGNYVSADT | EERLNEHQQV | TIPEEKVIKS | GDHFVLKEDP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SIRLIPRVYK | MSKSRGNVVN | PDDVVLEYGA | DSLRLYEMFM | GPFRDSKTWN | TSGIEGVHRF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LARTWRLVIG | LPQSDGSFKD | GTLVTDDEPT | LEQLRTLHKC | IAKVTEEIES | TRFNTGISGM |
| 850 | 860 | 870 | 880 | 890 | 900 |
| MEFVNAAYKW | NNQPRGIIEP | FVLLLSPYAP | HMAEELWSRL | GHPNSLAYES | FPKANPDYLK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NTTIVLPVQI | NGKTRGTIEV | EEGCSEDDAF | VLASQDDKLR | KYLDGQSIKK | RIYVPGKILN |
| 970 | |||||
| VILDRTNVKV | TTK |