Q9X909
Gene name |
topA |
Protein name |
DNA topoisomerase 1 |
Names |
DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme |
Species |
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) |
KEGG Pathway |
sco:SCO3543 |
EC number |
5.6.2.1: Enzymes altering nucleic acid conformation |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9X909
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9X909-F1 | Predicted | AlphaFoldDB |
No variants for Q9X909
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9X909 | |||||
No associated diseases with Q9X909
11 regional properties for Q9X909
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA topoisomerase, type IA, domain 2 | 125 - 213 | IPR003601 |
| domain | DNA topoisomerase, type IA, DNA-binding domain | 287 - 554 | IPR003602 |
| domain | TOPRIM domain | 12 - 135 | IPR006171 |
| domain | DNA topoisomerase, type IA, central | 99 - 112 | IPR013497-1 |
| domain | DNA topoisomerase, type IA, central | 149 - 595 | IPR013497-2 |
| active_site | DNA topoisomerase, type IA, active site | 324 - 338 | IPR023406 |
| repeat | Topoisomerase C-terminal repeat | 642 - 693 | IPR025589-1 |
| repeat | Topoisomerase C-terminal repeat | 701 - 764 | IPR025589-2 |
| repeat | Topoisomerase C-terminal repeat | 771 - 822 | IPR025589-3 |
| repeat | Topoisomerase C-terminal repeat | 834 - 886 | IPR025589-4 |
| domain | DNA topoisomerase 1, TOPRIM domain | 12 - 146 | IPR034149 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.6.2.1 | Enzymes altering nucleic acid conformation |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA topoisomerase type I (single strand cut, ATP-independent) activity | Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| chromosome segregation | The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. |
| DNA topological change | The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSPTSETAKG | GRRLVIVESP | AKAKTIKGYL | GPGYVVEASV | GHIRDLPSGA | AEVPEKYTGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VRRLGVDVEH | DFQPIYVVNA | DKKSQVKKLK | DLLKESDELF | LATDEDREGE | AIAWHLQEVL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KPKIPVKRMV | FHEITKDAIR | AAVANPRELN | QKLVDAQETR | RILDRLYGYE | VSPVLWKKVM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PRLSAGRVQS | VATRLVVERE | RERIAFRSAE | YWDLTGTFAT | GRAGDASDPS | SLVARLQTVD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GRRVAQGRDF | DSLGQLKSAN | TLHLDEANAR | ALAAALENTR | FAVRSVESKP | YRRSPYAPFR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TTTLQQEASR | KLGFGAKSTM | QVAQKLYENG | YITYMRTDST | TLSDTAVSAA | RAQVTQLYGA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DYLPPQPRTY | AGKVKNAQEA | HEAIRPSGDR | FRTPAETGLT | GDQFKLYELI | WKRTVASQMK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DATGNSVTVK | IGGAASDGRD | VEFSASGKTI | TFHGFLKAYV | EGADDPNAEL | DDRERRLPQV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AEGDALTAEE | ITVDGHATKP | PARYTEASLV | KELEEREIGR | PSTYASIIGT | ILDRGYVFKK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GTALVPSFLS | FAVVNLLEKH | FGRLVDYDFT | ARMEDDLDRI | ARGEAQSVPW | LRRFYFGEGD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GTGGGGAADA | GNGDGDHLGG | LKELVTDLGA | IDAREVSSFP | VGNDIKLRVG | RYGPYVERGE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KDAENHQRAD | VPEDLAPDEL | SVELAEELLA | KPSGDFELGT | DPATGHAIVA | KDGRYGPYVT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EVLPEGTPKT | GKNAVKPRTA | SLFKSMSLDT | VTLDDALKLM | SLPRVVGADA | EGVEITAQNG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RYGPYLKKGT | DSRSLQTEDQ | LFEITLEEAL | AIYAQPKQRG | RAAAKPPLKE | LGTDPVSEKP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VVVKDGRFGP | YVTDGETNAT | LRSDDSVEEI | TPERGYELLA | EKRAKGPAKK | TAKKAVKKTA |
| 910 | 920 | 930 | 940 | 950 | |
| AKKAPAKKAA | ATKKTAAAKT | TAAKKTAAKS | TAKKTTAKTA | AKKATASKTS | ED |