Q9X7F0

PR
Gene name
dnaE (ML1207, MLCB458.21)
Protein name
DNA polymerase III subunit alpha
Names
Species
Mycobacterium leprae (strain TN)
KEGG Pathway
mle:ML1207
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

707-776 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9X7F0

Entry ID Method Resolution Chain Position Source
AF-Q9X7F0-F1 Predicted AlphaFoldDB

No variants for Q9X7F0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9X7F0

No associated diseases with Q9X7F0

5 regional properties for Q9X7F0

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 7 - 74 IPR003141
domain PHP domain 8 - 194 IPR004013
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 316 - 586 IPR011708
domain DNA polymerase, helix-hairpin-helix motif 831 - 918 IPR029460
domain DNA polymerase III alpha subunit finger domain 589 - 758 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNQSSFVHLH NHTEYSMLDG AAKITPMFAE VERLQMPAVG MTDHGNMFGA SEFYNTAIKA
70 80 90 100 110 120
GIKPIIGVEA YIAPGSRFDT RRITWGDPSQ KADDVSAGGA YTHLTMVAEN AAGLRNLFKL
130 140 150 160 170 180
SSLASFEGQL SKWSRMDAEL IGEYAEGIIV TTGCPSGEVQ TRLRLGHDRE ALESAAKWRE
190 200 210 220 230 240
IVGPDNYFLE LMDHGLSIEQ RVREGLLNIG RKLNIPPLAT NDCHYVTRDA VHNHEALLCV
250 260 270 280 290 300
QTGKTLSDPN RFKFHGDGYY LKSAAEMRQL WDDEVPGACD STLLIAERVQ SYADVWEPRN
310 320 330 340 350 360
RMPVFPVPVG HDQASWLRHE VDAGLKRRFP DGPPNGYVER AAYEIDVICD KGFPAYFLIV
370 380 390 400 410 420
ADLVNHARSV GIRVGPGRGS AAGSLAAYAL GITDIDPIPH GLLFERFLNP ERTSMPDIDI
430 440 450 460 470 480
DFDDRRRGEM VRYAADKWGH DRVAQVITFG TIKTKAALKD SARIHYGQPG FAMADRITKA
490 500 510 520 530 540
LPPAIMAKDI PLSGITDPAH ERFKEAAEVR SLIETDSDVR IIYQTARGLE GLIRNAGVHA
550 560 570 580 590 600
CAVILSSEPL TEAIPLWKRP QDGAIITGWD YPACEAIGLL KMDFLGLRNL TIIGDAIENI
610 620 630 640 650 660
KTNRGIDLDL ESVPLDDQAT YELLGRGDTL GVFQLDGGPM RDLLRRMQPT GFEDIVAVLA
670 680 690 700 710 720
LYRPGPMGMN AHNDYADRKN NRQVIKPIHP ELEEPLREIL AETYGLIVYQ EQIMRIAQKV
730 740 750 760 770 780
AGYSLARADI LRKAMGKKKR EVLEKEFEGF SEGMQANGFS VHAIKALWDI ILPFADYAFN
790 800 810 820 830 840
KSHAAGYGLI SYWTAYLKAN FAGEYMAGLL TSVGDDKDKA AVYLADCRKF GITVLPPDVN
850 860 870 880 890 900
ESVLDFASVG ADIRYGLGAV RNVGANVVGS LIKTRNAKGK FADFSDYLNK IDITSCNKKV
910 920 930 940 950 960
TESLIKAGAF DSLGHSRKGL FLVHADAVDS VLGTKKAEAI GQFDLFGGTD GGTDAVFTIK
970 980 990 1000 1010 1020
VPDDEWEDKH KLALEREMLG LYVSGHPLNG VAHLLAAQVD TAIPTILDGG VSNDTQVRVG
1030 1040 1050 1060 1070 1080
GILAAVNRRV NKNGIPWASA QLDDLTGGIE VMFFPHTYSS YGADIIDDAV VLVNAKVVVR
1090 1100 1110 1120 1130 1140
DDRIALIANQ LVVPDFSNVQ EDRPLAVSLL TRQCTFDKVN ALKQVLARHP GTSQVHLRLI
1150 1160 1170
SGDRITTLEL DQSLRVTSSP ALMGDLKALL GPGCLGD