Q9X7E5

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Mycobacterium leprae (strain TN)
KEGG Pathway
mle:ML1195
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9X7E5

Entry ID Method Resolution Chain Position Source
AF-Q9X7E5-F1 Predicted AlphaFoldDB

No variants for Q9X7E5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9X7E5

No associated diseases with Q9X7E5

4 regional properties for Q9X7E5

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 59 - 70 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 28 - 671 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 719 - 857 IPR013155
domain Isoleucyl tRNA synthetase type 2, anticodon-binding domain 681 - 843 IPR033709

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTNSAYPRTD LGADQRGGSP NFPALEAQVL DYWSNDDTFR ASIARCDDAP EYVFYDGPPF
70 80 90 100 110 120
ANGLPHYGHL LTGYVKDIVP RYRTMCGYKV ERRFGWDTHG LPAELEVERQ LGITDKSQID
130 140 150 160 170 180
AMGIAAFNEA CRKSVLRYTE EWQAYVTRQA RWVDFDNDYK TLDLSYMESV IWAFKQLWDK
190 200 210 220 230 240
GLAYESYRVL PYCWRDETPL SNHELRMDDD VYQSRQDPAV TLGFKVLGGD DEDLVGAYLL
250 260 270 280 290 300
VWTTTPWTLP SNLAVAVHPD VTYVDVRAGD RRFVLAQARL TAYARELGDE PEVLATYRGA
310 320 330 340 350 360
DLLGRHYLPP FQYFYESARN AFQVLPGDFV TTDDGTGIVH IAPAYGEDDM ATADKVGIVP
370 380 390 400 410 420
VTPVDSNGCF DATVPDYQGQ HVFEANAQII RDLKNQSGSA AVNGAVLLRH ETYEHPYPHC
430 440 450 460 470 480
WRCRNPLIYR AVSSWFVAVT EFRDRMVELN QQITWYPEHV KDGQFGKWLQ GARDWSISRN
490 500 510 520 530 540
RYWGTPIPVW KSDDPDYPRI DVYGSLDELE RDFGVRPTNL HRPYIDELTR PNPDDPTGLS
550 560 570 580 590 600
TMRRIPDVFD VWFDSGSMPY AQVHYPFEND DWFDGFDSAD SDKQVDAHYP GDFIVEYIGQ
610 620 630 640 650 660
ARGWFYTLHV LATALFDRPA FKTCIAHGVV LGSNGQKMSK SLRNYPDVTE IFDRDGSDAM
670 680 690 700 710 720
RWFLMASPIL RGGNLIITEP GIREGMRQVL LPLWNAYSFL ALYAPKIGTW HTDVSHVLDR
730 740 750 760 770 780
YILAKLAVLR DDLSQAMEVC DISGACEQLR QFTEPLTNWY LRRSRARFWD EDVDAIDTLH
790 800 810 820 830 840
TVLEVTARLA APLLPLITEI IWRSVTGGRS VHLTDWPQAN QLPADPDLVA VMDQVRQVCS
850 860 870 880 890 900
AASSLRKAKK LRVRLPLPKL VVAVYNSQRL KPYIDLIGDE LNVKQIELTD AIDTYGRFEF
910 920 930 940 950 960
TVNARVAGPR LGRDVQAAIK VVKAGEGVAN PDGTLTAGPV VLQPDEYSSR LVAANPEFTA
970 980 990 1000 1010 1020
ELPDGSGLVV LDDTVTPELE AEGWAKDRIR ELQELRKLIG LDVSDRIRVL MSVPAERADW
1030 1040 1050
ARVHRDFIAR EILATSFEFG EPADSVAIGD GVRVSLLKV