Q9X7C0

PR
Gene name
hisH (ML1260, MLCB1610.23)
Protein name
Imidazole glycerol phosphate synthase subunit HisH
Names
IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH
Species
Mycobacterium leprae (strain TN)
KEGG Pathway
mle:ML1260
EC number
3.5.1.2: In linear amides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

8-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9X7C0

Entry ID Method Resolution Chain Position Source
AF-Q9X7C0-F1 Predicted AlphaFoldDB

No variants for Q9X7C0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9X7C0

No associated diseases with Q9X7C0

1 regional properties for Q9X7C0

Type Name Position InterPro Accession
domain Glutamine amidotransferase 8 - 199 IPR017926

Functions

Description
EC Number 3.5.1.2 In linear amides
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
glutaminase activity Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
imidazoleglycerol-phosphate synthase activity Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+).
lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

2 GO annotations of biological process

Name Definition
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRSKSVVVLD YGSGNLWSVQ RALQRVGAAV EVTADSAAGA AADGLLVPGV GAFEACMAGL
70 80 90 100 110 120
RKIAGERTIA ERIVAGRPVL GVCVGMQILF ARGVEFGVET TGCRQWPGVV TRLDAPVVPH
130 140 150 160 170 180
MGWNVVDSAS GSALFKGLDA GVRFYFVHSY AAQRWEGSSK ALLTWATHQV PFLAAVEEGP
190 200
LVATQFHPEK SGDAGATLLS NWLGEL