Q9X6Y2
Gene name |
rpoC |
Protein name |
DNA-directed RNA polymerase subunit beta' |
Names |
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta' |
Species |
Aquifex pyrophilus |
KEGG Pathway |
|
EC number |
2.7.7.6: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9X6Y2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9X6Y2-F1 | Predicted | AlphaFoldDB |
No variants for Q9X6Y2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9X6Y2 | |||||
No associated diseases with Q9X6Y2
7 regional properties for Q9X6Y2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA polymerase, alpha subunit | 474 - 511 | IPR000722-1 |
| domain | RNA polymerase, alpha subunit | 517 - 615 | IPR000722-2 |
| domain | RNA polymerase, N-terminal | 366 - 644 | IPR006592 |
| domain | RNA polymerase Rpb1, domain 3 | 619 - 760 | IPR007066 |
| domain | RNA polymerase Rpb1, domain 1 | 11 - 472 | IPR007080 |
| domain | RNA polymerase Rpb1, domain 5 | 880 - 1500 | IPR007081 |
| domain | RNA polymerase Rpb1, domain 4 | 789 - 877 | IPR007083 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.6 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| DNA-directed RNA polymerase complex | A protein complex that possesses DNA-directed RNA polymerase activity. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| zinc ion binding | Binding to a zinc ion (Zn). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTKGRGIFP | FSKIKLMLAS | PDDIRSWSHG | EVKRPETLNY | RTLKPEKDGL | FCAKIFGPTK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DYECLCGKYR | GKRYEGKICE | KCGVEVTSSY | VRRERFGHIE | LAAPVVHIWF | LKSTPSKIGT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLNLTSRDVE | RVAYFESYLV | IEYPNEEEEE | KFEKEEGTIP | LNDGISTKWV | KLHVVNEEEF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EEKYAFSIDE | KYEYGMGAEI | LKEVLSKIDL | EAYSKKLKEL | VKPYSLGFED | LGREVAEKYK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NLYQKLVKVI | ADDFRAYGVE | LKGLEDKGLT | LEQAIHRIIT | EELYLNVETG | EVEFEDCGDN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CLTGREALRV | YYEKVREHKR | DIPIFEKIKE | DVRTAVLREV | SEARIRKALR | ILQLVEGFKK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SGNRPEWMIL | EVLPVIPPEL | RPLVALDGGR | FATSDLNDLY | RRVINRNNRL | KRLIELSAPD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IIIRNEKRML | QEAVDALIDN | GKRGNPVKQN | GRPLKSLADY | LKGKQGRFRQ | NLLGKRVDYS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GRSVIVVGPE | LQMHQCGLPK | IMALELFKPF | VYRRLEEKGY | ATSIKHAKKL | VEQKTPEVWE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CLEEVVKQHP | VLLNRAPTLH | RPSIQAFEPV | LVEGKAIQLH | PLVCPPFNAD | FDGDQMAVHV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PLGIEAQLES | YILMLSTQNI | LSPAHGKPLT | MPSQDMVLGT | YYMTHDPIPG | RKGEGKAFTS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YEEVIKALEL | GHVDIHAKIK | FKVGKEWIET | TPGRVLFNSI | MPEGQPFVNE | TLDKKRLSKL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ITNLYIAVGN | EETVKFLDRV | KELGFLRSTL | AGISIGIDDL | QVPKVKEKII | KEALKKTEEI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| WNQYVQGIIT | NKERYNRIID | VWSEATNAVS | KAMFEEIEHS | TEIRNGKEYP | GTFNPIYMMA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VSGARGNRDQ | IRQLAGMRGL | MAKHSGEFIE | TPIISNFREG | LSVLEYFIST | YGARKGLADT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ALKTAFAGYL | TRRLVDVAQD | ITITEKDCGT | VKGFEMEPIV | EAGEERVPLK | DRIFGRVLAE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| DVKDPYTGEV | IAKRNEVVDE | KLAERIARAG | IEKVKVRSPL | TCEAKHGVCA | MCYGWDLSQR |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| KIVSVGEAVG | IIAAQSIGEP | GTQLTMRTFH | IGGAATAQKV | QSFVKTESEG | TVKFYNVKFI |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| VNRKGEKINV | SKDAAIGVLD | EKGRLLERHT | IPYGARLLVD | EGQKVKAGTK | LADWDPFNTY |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| IIAEVGGKIE | LRDIILDVTV | REERDVITGK | TATVVSFMRP | KDAMLHTPRI | AVITEDGKEY |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| VYDLPVNAIL | NIPADKLTLE | WRICPTCSES | EETTIQHQYY | VVKELEVQPG | DILARIPKET |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| AKVRDIVGGL | PRVEELFEAR | KPKNPAILSE | IDGYVKIYED | ADEVIVFNPR | TGETKKYAIK |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| KDELILVRHG | QYIKKGQKIT | ETKVAEIDGQ | VRIKGRGFKV | IVYNPETGLQ | REYFVPKGKF |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| LLVKEGDYVK | AGDPLTDGTP | VPEEILRIKG | IEELEKFLLK | EVQMVYKLQG | VDINDKHFEI |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| IIRQMLKKVR | IIDPGDSRFL | VGEEVDKEEL | EEEIQRIKLE | GGKLPKAEPV | LVGITRAALS |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| TRSWISAASF | QETTRVLTDA | SVEGKIDELR | GLKENVIIGN | LIPAGTGVDE | YKEVDVIPAE |
| 1570 | |||||
| EKVLEEKPQS | SEEETS |