Q9X1W3

PR
Gene name
prs
Protein name
Ribose-phosphate pyrophosphokinase
Names
RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase
Species
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
KEGG Pathway
tma:TM1628
EC number
2.7.6.1: Diphosphotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

134-239 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9X1W3

Entry ID Method Resolution Chain Position Source
AF-Q9X1W3-F1 Predicted AlphaFoldDB

No variants for Q9X1W3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9X1W3

No associated diseases with Q9X1W3

3 regional properties for Q9X1W3

Type Name Position InterPro Accession
domain Phosphoribosyltransferase domain 152 - 278 IPR000836
conserved_site Phosphoribosyl pyrophosphate synthetase, conserved site 131 - 146 IPR000842
domain Ribose-phosphate pyrophosphokinase, N-terminal domain 7 - 123 IPR029099

Functions

Description
EC Number 2.7.6.1 Diphosphotransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
ribose phosphate diphosphokinase complex A protein complex having ribose phosphate diphosphokinase activity.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
magnesium ion binding Binding to a magnesium (Mg) ion.
ribose phosphate diphosphokinase activity Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+).

4 GO annotations of biological process

Name Definition
5-phosphoribose 1-diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSFSNEMKVF SGNANRPLAE KIANYLNLQL GDCEVGRFAD GEINVRINET VRGHDIFLIQ
70 80 90 100 110 120
PTSPPVNENL MELLIMIDAF KRASANTIAV VIPYYGYARQ DRKAKGRDPI SAKLVANLIT
130 140 150 160 170 180
VAGATRVLTV DLHAEQIQGF FDIPVDNLWS YPVFAEELLK RENIVPEETV VVSPDVGGVR
190 200 210 220 230 240
RARRMAERLG TSLAILDKRR PSDNVAEVVN IIGEVEDKVV IMFDDIIDTA HSIVKGAEAL
250 260 270 280 290 300
KNAGAKRIIA CATHGVFSDR ALERIENSSI DTVYITDTIY HENLPEKVKV ISVANLIGEA
310
IMRIRKHLSV STLFR