Q9X1B6

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
KEGG Pathway
tma:TM1396
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

389-463 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9X1B6

Entry ID Method Resolution Chain Position Source
AF-Q9X1B6-F1 Predicted AlphaFoldDB

No variants for Q9X1B6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9X1B6

No associated diseases with Q9X1B6

4 regional properties for Q9X1B6

Type Name Position InterPro Accession
domain DHHA1 domain 731 - 862 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 650 - 693 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 553 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 706 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

6 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents.
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.
tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRYMTSEEIR EAFLKFFEKK GHKILPSASL IPDDPQLLFT VAGMVPFKPI FWGKVEPVYT
70 80 90 100 110 120
RVATCQKCLR TVDIENVGKT PRHHTFFEML GNFSFGDYFK EEAIEWAWEF LTQVLGVPEE
130 140 150 160 170 180
KLWVSVYEED EEAFRIWNEK IGLPEKRILR MGKEDNFWGP AGPTGPCGPD TEIFYDTGYS
190 200 210 220 230 240
KGCPEGEGCT PANSEGRFVE IWNLVFTEYY QDEEGKLHPL PRKNIDTGAG LERFCAMMQG
250 260 270 280 290 300
VYSNFDTDLF QPIIKRIEEL TGVGYKTDEE KDVSIRVIAD HIRAITFLIS EGVFPSNEGR
310 320 330 340 350 360
GYVLRRIIRR AMRHGILLGM SEPFLYRIVD AVVEKMGKVY PEIVRGEGMV KEVLSAEENR
370 380 390 400 410 420
FLKTLEQGMK VFDEIVEKKG KIDSEDAFRL YDTYGLPLEL TLEIAKEKGV EVDVQEFNKY
430 440 450 460 470 480
MEEQQRKSRA AMGDVEFARR YEYLEKLPKD FRTEFTGYEK LEDEGEVVLV ARDDETVEEA
490 500 510 520 530 540
SEGTVEVVFS RTPFYAEKGG QVSDTGMVEW RDGKALVEYV FEASEGVIVH RIKILDGTLR
550 560 570 580 590 600
RGQKVILRVD KKRREATMRN HTATHLLHAA LKKVLGDHVR QAGSLVAPDR LRFDFTHFKG
610 620 630 640 650 660
LSSAEIEQVE DLVNEWIMEA IPVEVRYTSY EEAVKSGVVA LFTEKYGDVV RVVEVPGVSK
670 680 690 700 710 720
ELCGGTHVKN TGQIGLFKII SEESVSSGVR RIEAVTGFSA LELLRNQKKL IDQLKEILGA
730 740 750 760 770 780
REDELTDRVL SLREKVKELE KKLSQGRISE ERIAMKQLED GVKVFHGVFE GVEAKHLGGI
790 800 810 820 830 840
ADNVLKKEGE GIVILFSKFE NKVSLVVKVS ENLLGKYDAS SIARNIAKEL GGNGGGRKNF
850 860
AQAGGRHPER IKDVLERLEE FLR