Q9WZH9

PR
Gene name
glyA
Protein name
Serine hydroxymethyltransferase
Names
SHMT, Serine methylase
Species
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
KEGG Pathway
tma:TM0720
EC number
2.1.2.1: Hydroxymethyl-, formyl- and related transferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

298-403 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9WZH9

Entry ID Method Resolution Chain Position Source
AF-Q9WZH9-F1 Predicted AlphaFoldDB

No variants for Q9WZH9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9WZH9

No associated diseases with Q9WZH9

No regional properties for Q9WZH9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9WZH9

Functions

Description
EC Number 2.1.2.1 Hydroxymethyl-, formyl- and related transferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
glycine hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
serine binding Binding to 2-amino-3-hydroxypropanoic acid.
zinc ion binding Binding to a zinc ion (Zn).

6 GO annotations of biological process

Name Definition
folic acid metabolic process The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
glycine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine.
L-serine catabolic process The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
tetrahydrofolate interconversion The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.
tetrahydrofolate metabolic process The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MWKHVKQVDP EIYEVLVNEL KRQEYGLELI ASENFASLAV IETMGSMLTN KYAEGYPKKR
70 80 90 100 110 120
YYGGCEWVDR AEERAIERAK RLFGAKFANV QPHSGSQANM AVYLALAQPG DTIMGMSLSH
130 140 150 160 170 180
GGHLTHGAPV NFSGKIFKVV PYGVNLETET IDYDEVRRLA LEHKPKIIVA GGSAYARIID
190 200 210 220 230 240
FKRFREIADE VGAYLMVDMA HFAGLVAAGI HPNPLEYAHV VTSTTHKTLR GPRGGLILTN
250 260 270 280 290 300
DPEIAKAVDK TIFPGIQGGP LMHVIAAKAV CFKEAMTEEF KEYQKQVVKN AKKMAEEFQK
310 320 330 340 350 360
RGYRIVSGGT DTHLFLVDLT PKDITGKAAE KALESCGITV NKNTIPNEKR SPFVASGIRI
370 380 390 400 410 420
GTPAVTTRGM KEEEMEEIAE MIDLVLSNVI DENGTVKPEV REEVSKKVRE LCERFPLYRD
KIEGVEI