Q9WZ44
Gene name |
queA (TM_0574) |
Protein name |
S-adenosylmethionine:tRNA ribosyltransferase-isomerase |
Names |
Queuosine biosynthesis protein QueA |
Species |
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) |
KEGG Pathway |
tma:TM0574 |
EC number |
2.4.99.17: Transferring other glycosyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9WZ44
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1VKY | X-ray | 200 A | A/B | 1-335 | PDB |
| AF-Q9WZ44-F1 | Predicted | AlphaFoldDB |
No variants for Q9WZ44
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9WZ44 | |||||
No associated diseases with Q9WZ44
1 regional properties for Q9WZ44
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Tubulin epsilon and delta complex protein 1 domain | 86 - 256 | IPR027996 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.99.17 | Transferring other glycosyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity | Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| queuosine biosynthetic process | The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. |
| tRNA wobble guanine modification | The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKVSEFDYEL | PPELIAQEPV | EPRDASRLMV | LHRKTQRIEH | RIFREIIEYL | EPGDLLVLNV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SKVIPARLYA | RKKTGASIEI | LLIERLEEGI | WKCLVRPGQK | VKKGTELVID | EDLSAVCLGR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GEDGTRILKF | QPQDDRLIFE | KGRTPLPPYI | KNEVPLERYQ | TVYAKEEGSV | AAPTAGLHFT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PELIEKLKKK | GVQFAEVVLH | VGIGTFRPVK | VEEVEKHKMH | EEFYQVPKET | VRKLRETRER |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GNRIVAVGTT | TVRTLETIAR | LPEQEEYVGK | TDLFIYPPFE | FKLVDALVTN | FHLPRSTLLM |
| 310 | 320 | 330 | |||
| LVAAFAGKDF | VMEAYREAVK | RRYRFFSFGD | AMLIL |