Q9WYW2
Gene name |
trpS |
Protein name |
Tryptophan--tRNA ligase |
Names |
Tryptophanyl-tRNA synthetase, TrpRS |
Species |
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) |
KEGG Pathway |
tma:TM0492 |
EC number |
6.1.1.2: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9WYW2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2G36 | X-ray | 250 A | A | 1-328 | PDB |
| AF-Q9WYW2-F1 | Predicted | AlphaFoldDB |
No variants for Q9WYW2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9WYW2 | |||||
No associated diseases with Q9WYW2
1 regional properties for Q9WYW2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aminoacyl-tRNA synthetase, class I, conserved site | 9 - 18 | IPR001412 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.2 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| tryptophan-tRNA ligase activity | Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tryptophanyl-tRNA aminoacylation | The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRILSGMRPT | GKLHIGHLVG | ALENWVKLQE | EGNECFYFVA | DWHALTTHYD | DVSKLKEYTR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DLVRGFLACG | IDPEKSVIFV | QSGVKEHAEL | ALLFSMIVSV | SRLERVPTYK | EIKSELNYKD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSTAGFLIYP | VLQAADILIY | KAEGVPVGED | QVYHIELTRE | IARRFNYLYD | EVFPEPEAIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SRVPKLPGTD | GRKMSKSYGN | IINLEISEKE | LEQTILRMMT | DPARVRRSDP | GNPENCPVWK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YHQAFDISEE | ESKWVWEGCT | TASIGCVDCK | KLLLKNMKRK | LAPIWENFRK | IDEDPHYVDD |
| 310 | 320 | ||||
| VIMEGTKKAR | EVAAKTMEEV | RRAMNLMF |