Q9WYC5

PR
Gene name
pfp
Protein name
Pyrophosphate--fructose 6-phosphate 1-phosphotransferase
Names
6-phosphofructokinase, pyrophosphate dependent, PPi-dependent phosphofructokinase, PPi-PFK, Pyrophosphate-dependent 6-phosphofructose-1-kinase
Species
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
KEGG Pathway
tmw:THMA_0296
EC number
2.7.1.90: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

369-419 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9WYC5

Entry ID Method Resolution Chain Position Source
AF-Q9WYC5-F1 Predicted AlphaFoldDB

No variants for Q9WYC5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9WYC5

No associated diseases with Q9WYC5

4 regional properties for Q9WYC5

Type Name Position InterPro Accession
conserved_site Phosphoglucose isomerase, conserved site 260 - 273 IPR018189-1
conserved_site Phosphoglucose isomerase, conserved site 486 - 503 IPR018189-2
domain Phosphoglucose isomerase, SIS domain 1 116 - 279 IPR035476
domain Phosphoglucose isomerase, SIS domain 2 326 - 507 IPR035482

Functions

Description
EC Number 2.7.1.90 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
6-phosphofructokinase activity Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate.
diphosphate-fructose-6-phosphate 1-phosphotransferase activity Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate.
metal ion binding Binding to a metal ion.
phosphofructokinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule.

2 GO annotations of biological process

Name Definition
fructose 6-phosphate metabolic process The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism.
response to glucose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAERLGILVG GGPAPGINSV ISSVTIEAIN NGLEVIGIYD GFKHLVEGKT NMVKKLSIED
70 80 90 100 110 120
VSRIHIEGGS ILRTSRVNPA KSEETLEKTV QTLKKLGIKY LVTIGGDDTA FSASKVCERS
130 140 150 160 170 180
KGEIKVVHVP KTIDNDLPLP ENMPTFGFET ARHVATELVY NLMQDSRTTN RWYFVAMMGR
190 200 210 220 230 240
EAGHLALGVG KAASATITII PEEFKEGVTL EEVCDVLDGA ILKRKLMGRD DGVAVIGEGI
250 260 270 280 290 300
AEKMDPEELA NIPGVIVEKD PHGHLRLAEI PLATILKRAI ERRYAERGER IHIVDVTIGY
310 320 330 340 350 360
ELRSARPIPF DIVYTRTLGY GAVRFLLGDY SDLPGGMVCV VGGRIKILPF DAFMDPKTGR
370 380 390 400 410
TKVRVVDVRS EDYRVARKYM IRLEKKDLED PETLEKLAKL AKMEPEEFKK KYWHTTELP