Q9WVM1

PR
Gene name
Racgap1
Protein name
Rac GTPase-activating protein 1
Names
Male germ cell RacGap, MgcRacGAP
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:26934
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

109-314 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9WVM1

Entry ID Method Resolution Chain Position Source
AF-Q9WVM1-F1 Predicted AlphaFoldDB

20 variants for Q9WVM1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389368746 5 M>V No EVA
rs240266557 10 T>A No EVA
rs216179734 23 N>S No EVA
rs3406602952 29 I>N No EVA
rs3404923332 32 I>N No EVA
rs3389389772 259 D>E No EVA
rs3389339928 282 T>I No EVA
rs235651788 351 M>V No EVA
rs3389368790 373 E>D No EVA
rs3389400219 428 R>H No EVA
rs3389386204 492 M>I No EVA
rs3405978621 511 P>A No EVA
rs3406398647 543 F>Y No EVA
rs3410377129 570 S>DG* No EVA
rs3406398645 592 S>L No EVA
rs3406398599 593 Q>E No EVA
rs3389389834 597 N>H No EVA
rs3389359793 613 T>S No EVA
rs3389395886 620 K>N No EVA
rs3389307112 629 K>Y No EVA

No associated diseases with Q9WVM1

2 regional properties for Q9WVM1

Type Name Position InterPro Accession
domain Rho GTPase-activating protein domain 350 - 540 IPR000198
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 287 - 336 IPR002219

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cytoplasm, cytoskeleton, spindle
  • Cytoplasmic vesicle, secretory vesicle, acrosome
  • Cleavage furrow
  • Midbody, Midbody ring
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • During interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the central spindle and, in telophase and cytokinesis, to the midbody ring, also called Flemming body
  • Colocalizes with RHOA at the myosin contractile ring during cytokinesis
  • Colocalizes with ECT2 to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis
  • Colocalizes with Cdc42 to spindle microtubules from prometaphase to telophase (By similarity)
  • Colocalizes with RND2 in Golgi-derived proacrosomal vesicles and the acrosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

11 GO annotations of cellular component

Name Definition
acrosomal vesicle A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
centralspindlin complex A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals).
cleavage furrow The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
extrinsic component of cytoplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
Flemming body A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge.
midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
mitotic spindle A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
spindle midzone The area in the center of the spindle where the spindle microtubules from opposite poles overlap.

8 GO annotations of molecular function

Name Definition
alpha-tubulin binding Binding to the microtubule constituent protein alpha-tubulin.
beta-tubulin binding Binding to the microtubule constituent protein beta-tubulin.
gamma-tubulin binding Binding to the microtubule constituent protein gamma-tubulin.
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
metal ion binding Binding to a metal ion.
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
phosphatidylinositol-3,4,5-trisphosphate binding Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

10 GO annotations of biological process

Name Definition
actomyosin contractile ring assembly The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.
mitotic cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
mitotic spindle midzone assembly The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone.
neuroblast proliferation The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.
positive regulation of cytokinesis Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
regulation of attachment of spindle microtubules to kinetochore Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore.
regulation of embryonic development Any process that modulates the frequency, rate or extent of embryonic development.
Rho protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
sulfate transport The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H0H5 RACGAP1 Rac GTPase-activating protein 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MDTTMVNLWT LFEQLVRRME IINEGNESIE FIQVVKDFED FRKKYQRTNQ ELEKFKDLLL
70 80 90 100 110 120
KAETGRSALD VKLKHARNQV DVEIKRRQRA EAECAKLEQQ IQLIRDILMC DTSGSIQLSE
130 140 150 160 170 180
EQKSALAFLN RGQASSGHAG NNRLSTIDES GSILSDISFD KTDESLDWDS SLVKNFKMKK
190 200 210 220 230 240
REKRRSNSRQ FIDGPPGPVK KTCSIGSTVD QANESIVAKT TVTVPSDGGP IEAVSTIETL
250 260 270 280 290 300
PSWTRSRGKS GPLQPVNSDS ALNSRPLEPR TDTDNLGTPQ NTGGMRLHDF VSKTVIKPES
310 320 330 340 350 360
CVPCGKRIKF GKLSLKCRDC RLVSHPECRD RCPLPCIPPL VGTPVKIGEG MLADFVSQAS
370 380 390 400 410 420
PMIPAIVVSC VNEIEQRGLT EAGLYRISGC DRTVKELKEK FLKVKTVPLL SKVDDIHVIC
430 440 450 460 470 480
SLLKDFLRNL KEPLLTFWLS KAFMEAAEIT DEDNSTAAMY QAVSELPQAN RDTLAFLMIH
490 500 510 520 530 540
LQRVSQSPDT KMDIANLAKV FGPTIVAHTV PNPDPVTMFQ DIKRQLKVVE RLLSLPLEYW
550 560 570 580 590 600
NQFMMVDQEN IDSQRGNGNS TPRTPDVKVS LLGPVTTPEF QLVKTPLSSS LSQRLYNLSK
610 620
STPRFGNKSK SATNLGQQGK FFPAPYLK