Q9WVB3
PR
Gene name |
Tle6 (Grg6) |
Protein name |
Transducin-like enhancer protein 6 |
Names |
Groucho-related protein 6 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:114606 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for Q9WVB3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 8H93 | EM | 301 A | B/E | 1-581 | PDB |
| 8H94 | EM | 290 A | B | 1-581 | PDB |
| 8H95 | EM | 338 A | B | 1-581 | PDB |
| 8H96 | EM | 278 A | B | 1-581 | PDB |
| AF-Q9WVB3-F1 | Predicted | AlphaFoldDB |
44 variants for Q9WVB3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs219364929 | 9 | D>G | No | EVA | |
| rs236406753 | 27 | V>M | No | EVA | |
| rs3389118863 | 33 | E>D | No | EVA | |
| rs1134547162 | 36 | S>R | No | EVA | |
| rs245637112 | 46 | E>D | No | EVA | |
| rs3389118014 | 52 | A>V | No | EVA | |
| rs3389116368 | 66 | P>A | No | EVA | |
| rs260965875 | 78 | V>L | No | EVA | |
| rs241330430 | 81 | E>G | No | EVA | |
| rs3389117530 | 83 | D>N | No | EVA | |
| rs221043952 | 95 | M>T | No | EVA | |
| rs3389059520 | 125 | S>G | No | EVA | |
| rs221865789 | 137 | F>C | No | EVA | |
| rs260775092 | 158 | C>Y | No | EVA | |
| rs3389095383 | 183 | G>S | No | EVA | |
| rs3389118078 | 196 | C>S | No | EVA | |
| rs3389122259 | 205 | R>G | No | EVA | |
| rs3389095401 | 231 | E>K | No | EVA | |
| rs3389116390 | 232 | D>Y | No | EVA | |
| rs211867574 | 244 | S>F | No | EVA | |
| rs3389113664 | 253 | P>S | No | EVA | |
| rs3389110301 | 264 | S>I | No | EVA | |
| rs261820155 | 271 | A>P | No | EVA | |
| rs3389117523 | 273 | W>* | No | EVA | |
| rs3389117568 | 282 | Q>H | No | EVA | |
| rs3389095325 | 325 | V>M | No | EVA | |
| rs247535140 | 336 | K>Q | No | EVA | |
| rs3412564209 | 347 | R>P | No | EVA | |
| rs3389122283 | 370 | V>L | No | EVA | |
| rs264674341 | 402 | A>T | No | EVA | |
| rs3389059505 | 440 | D>V | No | EVA | |
| rs3389095396 | 453 | C>W | No | EVA | |
| rs3389128219 | 472 | M>I | No | EVA | |
| rs3389118883 | 485 | L>Q | No | EVA | |
| rs3401527943 | 486 | G>V | No | EVA | |
| rs3401480921 | 489 | N>I | No | EVA | |
| rs3389084424 | 494 | L>M | No | EVA | |
| rs212768799 | 498 | R>S | No | EVA | |
| rs221859166 | 531 | G>A | No | EVA | |
| rs221859166 | 531 | G>D | No | EVA | |
| rs50131868 | 531 | G>S | No | EVA | |
| rs3389118924 | 560 | T>I | No | EVA | |
| rs50096865 | 563 | G>S | No | EVA | |
| rs3389084408 | 567 | I>F | No | EVA |
No associated diseases with Q9WVB3
4 regional properties for Q9WVB3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 283 - 320 | IPR001680-1 |
| repeat | WD40 repeat | 377 - 455 | IPR001680-2 |
| repeat | WD40 repeat | 499 - 538 | IPR001680-3 |
| repeat | WD40 repeat | 541 - 578 | IPR001680-4 |
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| subcortical maternal complex | Comprised of at least NLRP5, OOEP, TLE6, and KHDC3/KHDC3L with evidence of additional SCMC-associated proteins that interact with one or multiple members of the core complex. |
| transcription regulator complex | A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| transcription corepressor activity | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. |
| embryonic process involved in female pregnancy | A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother. |
| endoplasmic reticulum localization | Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell. |
| establishment of spindle localization | The directed movement of the spindle to a specific location in the cell. |
| mitochondrion localization | Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell. |
| negative regulation of canonical Wnt signaling pathway | Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of embryonic development | Any process that activates or increases the frequency, rate or extent of embryonic development. |
| positive regulation of neurogenesis | Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. |
| positive regulation of neuron differentiation | Any process that activates or increases the frequency, rate or extent of neuron differentiation. |
| regulation of cell division | Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. |
| spermatogonial cell division | The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes). |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9H808 | TLE6 | Transducin-like enhancer protein 6 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTSHRQSSDT | FGGILPSTLS | SRYLSIVNQL | PEEFSSVVSE | MMVHLENIFS | LAENFFQAIE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RFSRTPDLLE | RNKMSIGVGA | EGDSWPCHVS | HEAPMGSAQT | TENSAKEEDK | QVPESAALQH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PKFKSTPGPQ | LPTRRRFLSE | SDELQDPQPV | WDAEPQFCQG | FLIQGLWELF | MDSRQKNQQE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HGGEDSSQES | KDSGLCDFKP | EPQPRHRNSL | SDSADPFLIK | SPSALLDYYQ | EDVSRPQPET |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QESSGRADKF | LKPLSWGSEV | LESSCNQPST | ALWQLERFTV | PQALQKVRVL | KHQELLLVVA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VSSFTRHVFT | CSQSGIKVWN | LVNQVAEDRD | PESHLKCSVQ | DNKVYLRTCL | LSSNSRTLFA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GGYNLPGVIV | WDLAAPSLYE | KCQLPCEGLS | CQALANTKEN | MALAGFTDGT | VRIWDLRTQE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IVRNLKGPTN | SARNLVVKDD | NIWTGGLDAC | LRCWDLRMAK | VSLEHLFQSQ | IMSLAHSPTE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DWLLLGLANG | QHCLFNSRKR | DQVLTVDTKD | NTILGLKFSP | NGKWWASVGM | GNFITVHSMP |
| 550 | 560 | 570 | 580 | ||
| TGAKLFQVPE | VGPVRCFDMT | ENGRLIITGS | RDCASVYHIK | Y |