Q9WU61
Gene name |
Clcc1 (Mclc) |
Protein name |
Chloride channel CLIC-like protein 1 |
Names |
Mid-1-related chloride channel protein 1 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:170927 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9WU61
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9WU61-F1 | Predicted | AlphaFoldDB |
No variants for Q9WU61
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9WU61 | |||||
No associated diseases with Q9WU61
No regional properties for Q9WU61
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9WU61 | |||
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloride channel complex | An ion channel complex through which chloride ions pass. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| mitochondria-associated endoplasmic reticulum membrane | A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| chloride channel activity | Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| chloride transport | The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q99LI2 | Clcc1 | Chloride channel CLIC-like protein 1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLCSLLLCGC | LLLITGYAHD | DDWIDPTDML | NYDAASGTMR | KSQAKYGTSE | KKEVNPGLSD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AQELSDCLQR | LDSLTHKVDD | CEKKKMKDYE | SQSNPVFRRY | LNKILIEAGK | LGLPDEDRVD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VRYDAEILLT | RQTLLEIQKF | LSGEEWKPGA | LDDALSDILT | NFKSHDAEAW | KWQFEDYFGV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DPYNVFMVLL | CLLCIVALVA | TELWTYVRWH | TQLKRVCIIS | FLVSLGWNWI | YLYKVAFAQH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QANVAKMAPL | NDVCAKKMDW | TENLWEWFRI | SWTYKDDPCQ | KYYELLIVNP | IWLVPPTKAL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AVTFTNFVTE | PLKYIGKGTG | EFIKALMKEI | PVLLQIPVLV | ILALAVLGFC | YGAGQSVPML |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RHFRGPEREP | PRALEPDDRR | RQKELDYRFH | GGAGDADFSY | RGPAGSIEQG | PYDKMHVCER |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DVLRQRQVNM | RFPSGNKSPE | VLRAFDLPDT | EAQEHPEVVP | SHKPSIVNTS | LKETSELPRE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| STLAECSQCA | KDGSGQVPST | AESSPIVEKA | QLKTDSECRP | HSTEAAAAAA | RGTDPVSSPC |
| G |