Q9WU25

PR
Gene name
ADRA1A
Protein name
Alpha-1A adrenergic receptor
Names
Alpha-1A adrenoreceptor, Alpha-1A adrenoceptor, Alpha-1C adrenergic receptor
Species
Cavia porcellus (Guinea pig)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9WU25

Entry ID Method Resolution Chain Position Source
AF-Q9WU25-F1 Predicted AlphaFoldDB

No variants for Q9WU25

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9WU25

No associated diseases with Q9WU25

1 regional properties for Q9WU25

Type Name Position InterPro Accession
domain GPCR, rhodopsin-like, 7TM 43 - 326 IPR017452

Functions

Description
EC Number
Subcellular Localization
  • Nucleus membrane; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
  • Cytoplasm
  • Membrane, caveola
  • Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes
  • Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
caveola A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
alpha1-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.

3 GO annotations of biological process

Name Definition
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
regulation of cardiac muscle contraction Any process that modulates the frequency, rate or extent of cardiac muscle contraction.
regulation of vasoconstriction Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVFLSGNASD SSNCTQPPAP VNIPKAILLG VILGVLILFG VPGNILVILS VACHRHLHSV
70 80 90 100 110 120
THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN IWAAVDVLCC TASIMSLCII
130 140 150 160 170 180
SIDRYIGVSY PLRYPTIVTQ RRGLRALLCL WALSLVISIG PLFGWRQPAP QDETICQINE
190 200 210 220 230 240
DPSYVLFSAL GSFYVPLAII LVMYCRVYVV AKRESRGLTS GLKTDKSDSE QVTLRIHRKN
250 260 270 280 290 300
APLGGSGVAS SKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD
310 320 330 340 350 360
FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LKIQCLRRKQ SSKHALGYTL
370 380 390 400 410 420
HPPSQAVEGQ HKDMVRIPVG SRETFYKISK TDGVCEWKFF SSMPRGSARI TVPKDQSACT
430 440 450 460
TARVRSKSFL QVCCCVGPST PNPGENHQVP TIKIHTISLS ENGEEV