Q9WTR2

SS
Gene name
Map3k6 (Ask2, Mapkkk6, Mekk6)
Protein name
Mitogen-activated protein kinase kinase kinase 6
Names
EC 2.7.11.25 , Apoptosis signal-regulating kinase 2
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
2.7.11.25: Protein-serine/threonine kinases
Protein Class

Descriptions

Apoptosis signal-regulating kinases (ASK1-3) are MAP3Ks that trigger cellular responses to redox stress and inflammatory cytokines and play vital roles in innate immunity and viral infection. When activated, ASK1?3 activates JNK and p38 via phosphorylation of MAP2Ks (MKK3/4/6/7). ASK1?3 shares a conserved architecture in which the central kinase domain is flanked on either side by additional domains, and multimeric association appears to be crucial to the activity of these domains. Regulatory factors, such as thioredoxin, associate with the N-terminal thioredoxin-binding domain to negatively regulate activity. Activity can be induced by oxidation, thioredoxin dissociation, or TRAF association (among other stimuli), at which point the activating pleckstrin homology surface becomes available for MAP2K association, activation loop priming, and phosphorylation.

Autoinhibitory domains (AIDs)

53-230 (Thioredoxin-binding domain) SS

Target domain

649-907 (Protein kinase domain)

Relief mechanism

Partner binding, Others

Assay

Accessory elements

790-813 (Activation loop from InterPro)

Target domain

649-907 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9WTR2

Entry ID Method Resolution Chain Position Source
AF-Q9WTR2-F1 Predicted AlphaFoldDB

No variants for Q9WTR2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9WTR2

No associated diseases with Q9WTR2

9 regional properties for Q9WTR2

Type Name Position InterPro Accession
repeat Armadillo 92 - 175 IPR000225-1
repeat Armadillo 176 - 218 IPR000225-2
repeat Armadillo 220 - 259 IPR000225-3
repeat Armadillo 261 - 301 IPR000225-4
repeat Armadillo 303 - 344 IPR000225-5
repeat Armadillo 346 - 386 IPR000225-6
repeat Armadillo 389 - 429 IPR000225-7
domain Importin-alpha, importin-beta-binding domain 1 - 70 IPR002652
repeat Atypical Arm repeat 451 - 500 IPR032413

Functions

Description
EC Number 2.7.11.25 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase activity Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions

2 GO annotations of biological process

Name Definition
cellular response to stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6ZN16 MAP3K15 Mitogen-activated protein kinase kinase kinase 15 Homo sapiens (Human) SS
Q99683 MAP3K5 Mitogen-activated protein kinase kinase kinase 5 Homo sapiens (Human) EV
O95382 MAP3K6 Mitogen-activated protein kinase kinase kinase 6 Homo sapiens (Human) SS
A2AQW0 Map3k15 Mitogen-activated protein kinase kinase kinase 15 Mus musculus (Mouse) PR
O35099 Map3k5 Mitogen-activated protein kinase kinase kinase 5 Mus musculus (Mouse) SS
10 20 30 40 50 60
MAGPCPRAGV LERAGSCWQD PLAEALSRGR SSPAVTGRGC ARSRPLSVVY VLTREPGPGV
70 80 90 100 110 120
EPGSGTEAEP LPLRCLREAC AQLQGTRPPP QLRSLPFATL ALGDTAALDS FYNADVVVLE
130 140 150 160 170 180
VSSSLAQPSL FYHLGVRESF SMTNNVLLCS QAELPDLQAL REDVFQKNSD CVGSYTLIPY
190 200 210 220 230 240
VVTATGRVLC GDAGLLRGIA DGLVQAGAGT EALLTPLVGR LVRLLEATPT DSCGYFRETI
250 260 270 280 290 300
RQDIRQARER FSGQQLRQEL ARLQRRLDSV ELLSPDIVMN LLLSYRDVQD YSAIIELVET
310 320 330 340 350 360
LQALPTCDVA EQHNVCFHYT FALNRRNRPG DREKALAVLL PLVKYEGPVA PDLYCMCGRI
370 380 390 400 410 420
YKDMFFTSGF QNAGHLEQAY HWYRKAFDVE PSLHSGINAA VLLIAAGQHF EDSEELRLIG
430 440 450 460 470 480
MKLACLLARK GCVEKMQYYW DVGFYLGAQI LANDPIQVVL AAEQLYKLNA PIWYLVSVME
490 500 510 520 530 540
TFLLYQHFRP TPEPSGGPPL RAHFWLHFLL QSCQPFKMAP PQEDQCLVLV LEINKVLLPA
550 560 570 580 590 600
RLEIQGTDPM SAVTLSLLEP ETQEDPSSWT FPVTSICGIS TSKLDQRCCF LYALPPAQDV
610 620 630 640 650 660
QLCFPSVERC QRFCGLIQVL VMNPDSSAPT EEAEGAREVL EFDYEYSETG ERLVLGRGTY
670 680 690 700 710 720
GVVYAGRDRH TRVRIAIKEI PERDSRFSQP LHEEIALHKR LRHKNIVRYL GSASQGGYLK
730 740 750 760 770 780
IFMEEVPGGS LSSLLRSVWG PLKDNESTIS FYTRQILQGL SYLHENRIVH RDIKGDNVLI
790 800 810 820 830 840
NTFSGLLKIS DFGTSKRLAG ITPCTETFTG TLQYMAPEII DQGPRGYGKA ADIWSLGCTV
850 860 870 880 890 900
IEMATGRPPF HELGSPQAAM FQVGMYKVHP PVPGSLSAEA QAFLLRTFEP DPRLRASAQE
910 920 930 940 950 960
LLGDPFLQPG KRSRSPGSPR HTPRPSGAPS GPSSPSADSA TQSQTFPRPQ APSQHPPSPP
970 980 990 1000 1010 1020
KRCLSYGDTS QLRVPEEPAA EEPASPEESS GLSLLHQESK RRAMLAAVLE QEVPTLAENL
1030 1040 1050 1060 1070 1080
LEQEQDSRLS KIHVELLLRC LGAQIHTPNR RQLAQELRTL QAQLRAQSLG PALLKGPLFA
1090 1100 1110 1120 1130 1140
FPDAVKQILR RRQIRPHWMF VLDSLLSRAV RAALAVLDAE SEKKAVLPRS EESSKEESQQ
1150 1160 1170 1180 1190 1200
KPQESQALQS QLPPEQGPPS LMVELGLLRA ETDRLRDLLA EKERECQALV QQALHRVHAE
1210 1220 1230 1240 1250 1260
TRKYAPASET PATLPKDQNL VRWLQELSVD PATIQTLLSH SFTLQTLLTC ATQDDLVYTR
1270 1280 1290
IRGGMVCRIW RAILAQRAGA TSVTPVPRDA E