Q9W701

PR
Gene name
clcnkb
Protein name
Chloride channel protein ClC-Kb
Names
Chloride channel Kb, x6clck, xCIC-K
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:378616
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

158-231 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9W701

Entry ID Method Resolution Chain Position Source
AF-Q9W701-F1 Predicted AlphaFoldDB

No variants for Q9W701

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9W701

No associated diseases with Q9W701

9 regional properties for Q9W701

Type Name Position InterPro Accession
domain AAA+ ATPase domain 199 - 344 IPR003593-1
domain AAA+ ATPase domain 600 - 758 IPR003593-2
domain ATPase, AAA-type, core 204 - 308 IPR003959-1
domain ATPase, AAA-type, core 599 - 751 IPR003959-2
domain Clp, repeat (R) domain 1 - 147 IPR004176
conserved_site ClpA/B, conserved site 1 296 - 308 IPR018368
domain Clp ATPase, C-terminal 757 - 846 IPR019489
conserved_site ClpA/B, conserved site 2 634 - 652 IPR028299
domain ClpA/ClpB, AAA lid domain 344 - 446 IPR041546

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chloride channel complex An ion channel complex through which chloride ions pass.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
chloride channel activity Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
metal ion binding Binding to a metal ion.
voltage-gated chloride channel activity Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

2 GO annotations of biological process

Name Definition
chloride transport The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSRVLVIEQR EGEEKTLIQK HIFRPFPNTR RVVIDHLQRL KNFLFRIGDD WYFLFALGVI
70 80 90 100 110 120
MALISFTMDF TVSKMLNAHR WLQQELGGNV LLRYLSWIVY PIALVAFSTG FAQSITPHSG
130 140 150 160 170 180
GSGIPELKTI LSGVILEEYL TIKNFGAKVV GLTCTLSAGS TMFLGKVGPF VHLSSMIAAY
190 200 210 220 230 240
LGRMRTSVAG DYENKSKEHE MLVAAAAVGV STVFGAPISG VLFSVEVMSS HFAIRNYWRG
250 260 270 280 290 300
FFAATCGAFV FRLLAVFNSE QETITAVFKT SFKISFPFDL PEMFFFAILG VVCGLIGCAY
310 320 330 340 350 360
LFCQRWLLGY VRRNSLTSKL LASDKPMYSA LVALLISSIT FPESLGQFLA SRLTMKELLT
370 380 390 400 410 420
SLFDNRTWWI SLSQNSSLDR SPLVDPNNLW LEWANPQFTI FGTLAFFIIM KFWMFILATT
430 440 450 460 470 480
LPMPAGYFMP VFVFGAAIGR LVGETVALLY PEGIAADGIV NPIIPGGYAW QGAPAYSGAV
490 500 510 520 530 540
THSVSTALLA FEATGQIAHI LPVILCVLIA NAFTQKLQPS FYDGTIIVKK LPYLPRIRSR
550 560 570 580 590 600
DIDSYKVNTE EFMNPDIRVL PREAGFEDVL KVITASDDSE YPVVDNTESQ VLVGTVKRPQ
610 620 630 640 650 660
LIHFLETHES HERAGPTEKE NLSEGNLGEA CSIEPVTFQL STWTSLHQAH HLFELLHLQK
670 680
AFVTKYGRIV GQVTRKEMKK AIEDLANPK