Q9W484

PR
Gene name
Rtel1
Protein name
Regulator of telomere elongation helicase 1 homolog
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG4078
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

33-119 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9W484

Entry ID Method Resolution Chain Position Source
AF-Q9W484-F1 Predicted AlphaFoldDB

3 variants for Q9W484

Variant ID(s) Position Change Description Diseaes Association Provenance
81 G>D strain: ZW104 [UniProt] No
95 A>T strain: ZW141 [UniProt] No
294 Q>del strain: ZW104 and ZW141 [UniProt] No

No associated diseases with Q9W484

4 regional properties for Q9W484

Type Name Position InterPro Accession
domain Helicase-like, DEXD box c2 type 9 - 294 IPR006554
domain ATP-dependent helicase, C-terminal 546 - 725 IPR006555
domain RAD3-like helicase, DEAD 111 - 273 IPR010614
domain Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type 7 - 303 IPR014013

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
  • Chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

8 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
DNA polymerase binding Binding to a DNA polymerase.
metal ion binding Binding to a metal ion.

10 GO annotations of biological process

Name Definition
DNA duplex unwinding The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
male germ-line stem cell population maintenance The process by which an organism or tissue maintains a population of male germ-line stem cells.
negative regulation of DNA recombination Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.
negative regulation of response to DNA damage stimulus Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus.
negative regulation of t-circle formation Any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation.
regulation of double-strand break repair via homologous recombination Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
telomeric loop disassembly The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BX63 BRIP1 Fanconi anemia group J protein Homo sapiens (Human) PR
10 20 30 40 50 60
MPESLIAGIP VHFPFEPYPV QRAYMEKVIH CLRDGTNGVL ESPTGTGKTL SLLCSSLAWI
70 80 90 100 110 120
RTRQSEHQKQ MVKMEKADFS GLGGGAPGGD LSELAKTMGR ANNWGVPKVI YASRTHSQLT
130 140 150 160 170 180
QAMRELKRTA YANMRSVVLG SRDQLCIHPE VMREQGNSNK TNMCKLRVHS KTCSFQMRVE
190 200 210 220 230 240
SRKDHPDLRG PTIMDIEDLV KVGQRLKICP YFASRELVPQ ADITFMPYNY LLDPKARKAN
250 260 270 280 290 300
KIELGNTIVI LDEAHNIEKI CEESASVQIK SSDVAMAIED VTHIMQVFAS GESQDMAGDE
310 320 330 340 350 360
PKDFTLDDLT LLKEMLLELE KAIDAIVVDN AVDGTTFPAS MMYELLGKAN FTYGNVATIV
370 380 390 400 410 420
SLLDKLVQYL LVASQQMSIR KGGTFTLLSD LLTIVFANKE DVMSKVYASF KVHVLVEESK
430 440 450 460 470 480
QGHGKQQGAK QQGGWLGKGT IAAATGLSKV AKIINFWCFN PGFGMEQLLN TQVRSVILTS
490 500 510 520 530 540
GTLAPLKPLI AELAIPVAQH LENPHIVDQS QVYVKIIGTG PDRQQLISNY ANRDNPKYIS
550 560 570 580 590 600
SLGQTILNVA RIVPDGLLVF FPSYPMLNKC VDAWQASGLW ADISCKKPIF LEPRSKDQFT
610 620 630 640 650 660
STMEEFYQAI RDSKGAVFMA VCRGKVSEGL DFADRNGRAV IITGLPFPPL KDPKVILKRR
670 680 690 700 710 720
YLEANRTREN QLLSGQEWYN LDATRAVNQA IGRVIRHRND YGAILLCDSR FKDASQVQQL
730 740 750 760 770 780
SKWIRGHLGD RPQCSPFGPI VRELRQFFKN AEANMKLPDE RETDSPLETV CKTEDEPLAA
790 800 810 820 830 840
IPKVKREPGS NATFKSANES AIKVEMANSI KTWTPADYAS AAGHKLGGAA PNAMDFMSRL
850 860 870 880 890 900
DSNVSSIDFN CCTDSKSGSS GLVKIHKRER SSPTAPESSS QVTKKRYKLV ENIKVEPSSS
910 920 930 940 950 960
QAKEAPEERA AFLRELRSLV TQDQFRRFGK ALLEYKNGTY ESFQALMAIL LDVLSAPKVR
970 980
YMLVGMRKYL KNEHKDEFDR RVGNL