Q9W3K5

PR
Gene name
Gclc
Protein name
Glutamate--cysteine ligase
Names
Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG2259
EC number
6.3.2.2: Acid--amino-acid ligases (peptide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

48-118 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9W3K5

Entry ID Method Resolution Chain Position Source
AF-Q9W3K5-F1 Predicted AlphaFoldDB

No variants for Q9W3K5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9W3K5

No associated diseases with Q9W3K5

No regional properties for Q9W3K5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9W3K5

Functions

Description
EC Number 6.3.2.2 Acid--amino-acid ligases (peptide synthases)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
glutamate-cysteine ligase complex An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutamate-cysteine ligase activity Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate.

5 GO annotations of biological process

Name Definition
axonogenesis De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
glutathione biosynthetic process The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
imaginal disc-derived wing morphogenesis The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
response to copper ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P19468 Gclc Glutamate--cysteine ligase catalytic subunit Rattus norvegicus (Rat) PR
Q20117 gcs-1 Glutamate--cysteine ligase Caenorhabditis elegans PR
10 20 30 40 50 60
MGLLSEGSPL SWEETKALAD HVREHGVNQF INLYHRLKDR QGDILKWGDE VEYIIVKFDD
70 80 90 100 110 120
EQKVARVALR AQDLLAQLNE KELADPNGVK SLWRPEYGAY MIEGTPGKPF GGLMAHFNLV
130 140 150 160 170 180
EANMRYRREE VTELLAKDEC VMSITNFPRL GAPNFTYPLA QPRPEDPLSS ARSLYFPDEA
190 200 210 220 230 240
IFPGHPRFKT LTRNIRKRRG EKVSIKLKVF KDTKTKLPVE GAPPGEPDVV LLDAMGFGMG
250 260 270 280 290 300
CCCLQLTFQA CNITEARRLY DQLAPLCPIM LALTAASPIY RGYLTESDCR WNVISSSVDC
310 320 330 340 350 360
RTEEERGLAP LDQQKFRIAK SRYDSIDSYL SPEGAKYNDV PLTYDEKVYQ RLVEGGIDHL
370 380 390 400 410 420
LAQHVAHLFI RDTVSLFSEK VHQNDNEDTD HFENIQSTNW QTMRFKPPPP NSSIGWRVEF
430 440 450 460 470 480
RPCEAQISDF ENAAIVCFVV LLTRVILSYQ LNFLTPISKV DENMQTAQKR DACRKEKFWF
490 500 510 520 530 540
RKSSKTTEQR AAKAQAQAQA QAKAQAQTNG KATLNGNGLA NGNGNGSENS DQEEQQPLTN
550 560 570 580 590 600
GSAKMNGHGS GTTNGTNGSS NGSSNGTDSD HTDTDDEENE LFQLLSINEI FNGKPNVFPG
610 620 630 640 650 660
LVPLIRSYLQ SMEVDTDTHC TIEQYLRFIQ KRAAGELITT ATWMREQVLS HPDYKQDSVV
670 680 690 700 710
SERINYDLLK RIQGIQEGKQ VEPALLGQDY HSKTKTKDFI PPALQKQLAK NGCCEEK