Q9VXH9

PR
Gene name
SWIP
Protein name
WASH complex subunit 4
Names
Strumpellin and WASH-interacting protein homolog, WASH complex subunit SWIP homolog
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG13957
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1022-1093 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VXH9

Entry ID Method Resolution Chain Position Source
AF-Q9VXH9-F1 Predicted AlphaFoldDB

No variants for Q9VXH9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VXH9

No associated diseases with Q9VXH9

3 regional properties for Q9VXH9

Type Name Position InterPro Accession
domain WASH complex subunit 4, N-terminal 11 - 577 IPR028191
domain WASH complex subunit 7, central domain 592 - 911 IPR028282
domain WASH complex subunit 7, C-terminal 929 - 1102 IPR028283

Functions

Description
EC Number
Subcellular Localization
  • Early endosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
endosome A vacuole to which materials ingested by endocytosis are delivered.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
WASH complex A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
endosomal transport The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
endosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.
nuclear envelope budding The process by which large macromolecular complexes are budded through the inner nuclear membrane, into the perinuclear space, thus acquiring a membrane envelope. The enveloped particle fuses with the outer nuclear membrane and is released into the cytoplasm.
positive regulation of cell adhesion Any process that activates or increases the frequency, rate or extent of cell adhesion.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFAEDILRDY GSFISEHDGK LKLLRDKVPN RDVSESAQCV YMSPVVEVNF MGNDSMAPDR
70 80 90 100 110 120
SFEESELVAN KPLTTLANLC NQCRNLSRKA KRFQLAFLFS DFRLDDTLPP HTHTSEGSAG
130 140 150 160 170 180
LEGSLVRMSS SMDFFCQVYF LLNRMIVILQ NLWRQIAASV SVPMDINEVH IFAVFDAMSE
190 200 210 220 230 240
LLEHIVVFNE LANQSKISTM WALYKKWLMN LSNSQSANLE LNGLSTSLMD IENLITKDFF
250 260 270 280 290 300
RILLDNLMEL KKQFGLNSVS PITQHSNAYI RRQLLDVDAN PSNELKNYED PKHIIRLTTF
310 320 330 340 350 360
VVVVHELGIQ MEGKLVKNVI DLVARHKQVP LNRSVFWSPS GFLSLHAKTL MKSSARSQDG
370 380 390 400 410 420
QGPKVHSTVL EKFRLSDQRT CRQLGVQLSL WSIQMQRVFD VGVFGHLKTF LQLILNGHSY
430 440 450 460 470 480
ADQVNLLAVA LINRHVALMT PMTRNDWIVV SRLLQYLKVI QKTFESNQIN FVRFISSLIQ
490 500 510 520 530 540
WQKQKVIHLL HTTKKKIVVL KLLQRKINFL ATIKLAEKSI MGFPSKQRLT FVNLALGEFL
550 560 570 580 590 600
DNRLLPADNQ KLIKSILHRV NSISDIMRNI GGQLNTSESS SLVYNHWFLD TSVLKEYTEL
610 620 630 640 650 660
QRNPYSLQNL VSVSHHLDKI MAMFRGSRCP KQSANDLIIE FLSNHLEFFL RVEALSHLFQ
670 680 690 700 710 720
SQDQPFQQSA LDYRLCINAV AVENDGDYNI IKDHLENYFT ATFYNLTTIA PHDWKSYEKM
730 740 750 760 770 780
RHLANKVLQL QPIDDHLPNQ IIDQGIDVLQ IMRNIHTFAS SYAYNMNLQV FVETNSRSKH
790 800 810 820 830 840
LDIIGTRHVA NSVQTHGTGI INTTVNFIYQ FLRQKFYTFS TFLHDEQIKS RLLKELRFHT
850 860 870 880 890 900
EHKHSKSYQS YPYERADSFL KKIRRLGCSS NGETYMDLFR KVITQVGNAV GYVRLLQAGS
910 920 930 940 950 960
KNANFRNRSY KTRFDSNFSC GGSKVHEATE GSIREYEKSL GHMKECYSDS TNYFKLLLQG
970 980 990 1000 1010 1020
FQPFLCNPHN HHLRTFYLIT PALIMNYIDY RVKQKLKIYK KDQTKISLFE DGFAIGLVYI
1030 1040 1050 1060 1070 1080
LNMLNQQTEF HELGWSQTIT QHLNAERSKV RDILAGQQRT APEQLDEKLH QTVAITERHV
1090 1100
NAYEHEYNLL YATLSSSEIF FQ