Q9VTJ4
Gene name |
Fuca (CG6128) |
Protein name |
Putative alpha-L-fucosidase |
Names |
Alpha-L-fucoside fucohydrolase |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG6128 |
EC number |
3.2.1.51: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9VTJ4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9VTJ4-F1 | Predicted | AlphaFoldDB |
No variants for Q9VTJ4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9VTJ4 | |||||
No associated diseases with Q9VTJ4
1 regional properties for Q9VTJ4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Alpha-L-fucosidase, C-terminal | 376 - 492 | IPR031919 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.2.1.51 | Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| outer acrosomal membrane | The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction. |
| sperm plasma membrane | A plasma membrane that is part of a sperm cell. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha-L-fucosidase activity | Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose. |
| fucose binding | Binding to fucose, the pentose 6-deoxygalactose. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| binding of sperm to zona pellucida | The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. |
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| fucose metabolic process | The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. |
| glycosaminoglycan catabolic process | The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. |
| glycoside catabolic process | The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAISAWMPLL | VALIVVWISA | AEVDAQVPGP | RTRYQPNWAS | LDQRPLPQWY | DDAKVGIFLH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YGVYSVPSFG | SEWFWTNWKN | LRNPEYVQFM | QRNYKPDFTY | QEFASQFTAE | LFNATKWALL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FKDSGARYVV | LTSKHHDGFT | LWPSKNSYGW | NSMDVGPKRD | IVKELAAAIR | KESDLRFGLY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YSLFEWFNPL | WTDDKLHLLM | QQHFVERKVR | PEQMELVQQY | LPEIIWSDGD | WEAPAKYWRS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EEFIAWLYND | SPVRDTVVTN | DRWGFGTACM | HGDFYNCADR | FNPGVLQAHK | WENAFTLDRT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SWGQRFDVSL | SDFMTSKEVI | KEIITTVSCN | GNVLINVGPT | KFGTILPIFE | ERLRDMGRWL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KFNGEGIYGS | VPWIYQNDTI | NGNVWYTRQK | EASNGKITIY | AFVLEYPYDT | NELDIYPLGK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DINIFRNVML | TGIDMGTGGD | ILNEQSTEVV | MLGMEDTKIK | WNADHNRLHI | VFPPKNHIDK |
| 490 | |||||
| RGLDYAWTFK | ITIT |