Q9VSH2

PR
Gene name
Gr66a (CG7189)
Protein name
Gustatory receptor for bitter taste 66a
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG7189
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

194-345 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VSH2

Entry ID Method Resolution Chain Position Source
AF-Q9VSH2-F1 Predicted AlphaFoldDB

No variants for Q9VSH2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VSH2

No associated diseases with Q9VSH2

No regional properties for Q9VSH2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9VSH2

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
taste receptor activity Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.

8 GO annotations of biological process

Name Definition
chemosensory behavior Behavior that is dependent upon the sensation of chemicals.
detection of chemical stimulus involved in sensory perception of taste The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal.
response to caffeine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
response to insecticide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.
response to L-canavanine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus.
sensory perception of bitter taste The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
sensory perception of taste The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VM09 Gr28a Putative gustatory receptor 28a Drosophila melanogaster (Fruit fly) PR
Q9VKJ7 Gr32a Gustatory and pheromone receptor 32a Drosophila melanogaster (Fruit fly) PR
Q9VPT1 Gr21a Gustatory and odorant receptor 21a Drosophila melanogaster (Fruit fly) PR
Q9VZL7 Gr63a Gustatory and odorant receptor 63a Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
MAQAEDAVQP LLQQFQQLFF ISKIAGILPQ DLEKFRSRNL LEKSRNGMIY MLSTLILYVV
70 80 90 100 110 120
LYNILIYSFG EEDRSLKASQ STLTFVIGLF LTYIGLIMMV SDQLTALRNQ GRIGELYERI
130 140 150 160 170 180
RLVDERLYKE GCVMDNSTIG RRIRIMLIMT VIFELSILVS TYVKLVDYSQ WMSLLWIVSA
190 200 210 220 230 240
IPTFINTLDK IWFAVSLYAL KERFEAINAT LEELVDTHEK HKLWLRGNQE VPPPLDSSQP
250 260 270 280 290 300
PQYDSNLEYL YKELGGMDIG SIGKSSVSGS GKNKVAPVAH SMNSFGEAID AASRKPPPPP
310 320 330 340 350 360
LATNMVHESE LGNAAKVEEK LNNLCQVHDE ICEIGKALNE LWSYPILSLM AYGFLIFTAQ
370 380 390 400 410 420
LYFLYCATQY QSIPSLFRSA KNPFITVIVL SYTSGKCVYL IYLSWKTSQA SKRTGISLHK
430 440 450 460 470 480
CGVVADDNLL YEIVNHLSLK LLNHSVDFSA CGFFTLDMET LYGVSGGITS YLIILIQFNL
490 500 510 520
AAQQAKEAIQ TFNSLNDTAG LVGAATDMDN ISSTLRDFVT TTMTPAV