Q9VNJ5

PR
Gene name
disp (CG2019)
Protein name
Protein dispatched
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG2019
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

71-173 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q9VNJ5

Entry ID Method Resolution Chain Position Source
6TBU EM 316 A A 1-1218 PDB
6TD6 EM 476 A A 1-1218 PDB
AF-Q9VNJ5-F1 Predicted AlphaFoldDB

No variants for Q9VNJ5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VNJ5

No associated diseases with Q9VNJ5

1 regional properties for Q9VNJ5

Type Name Position InterPro Accession
domain Sterol-sensing domain 468 - 624 IPR000731

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoneme A long, thin, polarized cell projection that contains actin and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
transmembrane transporter activity Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

7 GO annotations of biological process

Name Definition
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
patched ligand maturation The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups.
pole cell migration The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form.
segment polarity determination Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products.
smoothened signaling pathway The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
wing disc pattern formation The process giving rise to the pattern of cell differentiation in the wing imaginal disc.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLCFDSERMN WYYHVLARRP YLVVVSIAVY CVACIIVALV LNKLPDFSDP TLGFETRGTK
70 80 90 100 110 120
IGERLTAWYN LLQETDHHGA LFSNPSDLWE RRRVEQGYVE TKLHPNHRRR KNKHKNRNKN
130 140 150 160 170 180
KRRKEQNQSS HEHHDVAQKM MQFKKRLKAT SSPSPNLGFD TWIGDSGVFR DYEITNDSAS
190 200 210 220 230 240
SSLEPTRRTE QIEYGHNTTS VDEEEHQQRV QTKKSTWRLL KQAATLPTDG WADMHRRQPI
250 260 270 280 290 300
EGFFCDSSPR KEYSHFVVQR IGPNATDSLF DLNGLLAMCQ LQDQITEVPS YRAFCEPEML
310 320 330 340 350 360
TTECCRPWSL PNYAAMLANK SSCFDLTTED VTSLHTLLLG CYEYFHDLKM DNHCNEIPHC
370 380 390 400 410 420
RAPEECKRLN IVFNVLNFLT DFSFIKSNDS NVYLKYAMIF IPVAQSNRLL PLFHEWEDVE
430 440 450 460 470 480
LINELVEVVA MDLGLENELF NELLLTDVWL VSLGGTFVMA SVWLYTGSAF ITLMSCVAIC
490 500 510 520 530 540
FSLGLAYFFY AIVLEFEFFP YMNLLAVVVI IGIGADDVFL FLKIWHCVLT ERFSNRCTLT
550 560 570 580 590 600
TQSQSALPTL ENSDHTESLE NIMALTMRHA AASMFVTSLT TAGAFYASYS SSITAIKCFG
610 620 630 640 650 660
IFAGTVVVTN YLLMITWLPA SVSIMERLFA TRMSCHHPMS IKLIHACKKS INRFCQMFEE
670 680 690 700 710 720
CITKSIMNYA YLWLLIFGAL GASSAVIVFW YPGLQLPEKS HFQLFVSKHP FEVYSSLKQQ
730 740 750 760 770 780
FWFEKPLQAY ENFKMHMHFV WGVQAVDDGD YTNPNSYGHL HYDNNFNVSS RPAQLWILDF
790 800 810 820 830 840
CQSVRQQPFY KETLGMLLPN CFIENLIDYM KRRCIDDMDS TRKDRSPCCD AQFPFEPHIF
850 860 870 880 890 900
EYCLPQSISN MYDTTFFRPG VAGPKFAEAP RLETEDYLGM SGNESAEYST NGSFTPLLVK
910 920 930 940 950 960
ALVIEFESNV AYSTIYANIR QFYESVEHWF QMQLKTAPPE LQGGWFTSDL KFYNVQDTLS
970 980 990 1000 1010 1020
HDTFVAICLA MAASLAVLLC FTVNILISIY AVLTVSLSIF NTVAVLILLG WQLNILESIA
1030 1040 1050 1060 1070 1080
VSTAIGLAVD FSLHYGIHYR MSPVKERLAA TQFVLSRIIG PTVMAATTTG LAGGIMMASN
1090 1100 1110 1120 1130 1140
ILPYIQIGVF LVVVMIVSWF YATFFLMSLL RVAGPQHGFL ELKWPLWSKR SSGSSKFYER
1150 1160 1170 1180 1190 1200
KPSQVIASEQ LLTPTSSAIV ELANSETHEL ESLNSNSLIK TISGIESAHA LSSLPRDFEH
1210
SFQTMHECKY QTYPSTSN