Q9VHN9

PR
Gene name
p
Protein name
BLOC-2 complex member HPS5 homolog
Names
Hermansky-Pudlak syndrome 5 protein homolog, Protein pink, dHPS5
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG9770
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

216-305 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VHN9

Entry ID Method Resolution Chain Position Source
AF-Q9VHN9-F1 Predicted AlphaFoldDB

No variants for Q9VHN9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VHN9

No associated diseases with Q9VHN9

No regional properties for Q9VHN9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9VHN9

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
BLOC-2 complex A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
pigment binding Binding to a pigment, a general or particular coloring matter in living organisms, e.g. melanin.

8 GO annotations of biological process

Name Definition
compound eye pigmentation Establishment of a pattern of pigment in the compound eye.
developmental pigmentation The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.
eye pigment biosynthetic process The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye.
negative regulation of post-transcriptional gene silencing by RNA Any process that stops, prevents or reduces the frequency, rate or extent of post-transcriptional gene silencing by RNA.
ommochrome biosynthetic process The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye.
protein targeting to lysosome The process of directing proteins towards the lysosome using signals contained within the protein.
response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UPZ3 HPS5 BLOC-2 complex member HPS5 Homo sapiens (Human) PR
P59438 Hps5 BLOC-2 complex member HPS5 Mus musculus (Mouse) PR
10 20 30 40 50 60
MADAYCLTNF IDFSLSLSLP LKHHNRIKYT CFDISDSYII FGASSGSLYL FNRNGKFLLL
70 80 90 100 110 120
IPNKHGAITS LSISANSKYV AFATQRSLIC VYAVNLSAQA TPQVIFTHLD QSVQVTCIHW
130 140 150 160 170 180
TQDEKQFYYG DSRGQVSLVL LSSFIGHSLL FNMTVHPLLY LDSPIVQIDD FEYLLLVSNC
190 200 210 220 230 240
TKCILCNTEY EDYKQIGNRP RDGAFGACFF VSPQESLQPS RIYCARPGSR VWEVDFEGEV
250 260 270 280 290 300
IQTHQFKTAL ATAPARIQRP GSGTDELDAN AELLDYQPQN LQFAKVQRLN DDFLLAFTEL
310 320 330 340 350 360
GLYIFDIRRS AVVLWSNQFE RIADCRSSGS EIFVFTQSGA LYSVQLQTLQ SHAVSLIQQS
370 380 390 400 410 420
KLLPCANLLR QHVRYFADKA REDYELKQLN PLKQLLIERQ EYELLNDISV IFDAITQCTG
430 440 450 460 470 480
SALDTHSSGG SSATTERSLS GGSSSRAPPK GVYVLENAFC DNLKQPLKTG HFKDALLTVT
490 500 510 520 530 540
GKFGKNIIKY KFNIFAEEQQ QLVRELIPAS ERSLPFKDIK ARYESGSEDQ EEEIVRRCKK
550 560 570 580 590 600
PAPQVPHISP EEKTLYNLYL IAKSAKFSRT QCVDRYRAVF DEYAAGELVN LLEKLAQVMV
610 620 630 640 650 660
EHGDTPDQAQ RNCYEMYFDY LDPEMIWEVD DATRDHIAAG FVLLNTSQNA EIVKCEHCSF
670 680 690 700 710 720
PLRFDTSCQY HELGAVLLRY FWSRGEQLKC FDVVQSVPAL LDVLAKFYLA EQNLTKVVAI
730 740 750 760 770 780
VLNYGLPELL ADVGKQLSVS AWGRCFEQFV ELQRGGRLVC ANCECISGVE QEQLGRHFFY
790 800 810 820
NWNCFLNIAL DHMSAGDTLA LIFKWSSYIP NDAIDREFYS RCLLKG