Q9VEZ5

PR
Gene name
IKKbeta
Protein name
Inhibitor of nuclear factor kappa-B kinase subunit beta
Names
I-kappaB kinase subunit beta, Cactus kinase IKK, IKK-like protein, Immune response deficient protein 5, Lipopolysaccharide-activated kinase, DLAK
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG4201
EC number
2.7.11.10: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VEZ5

Entry ID Method Resolution Chain Position Source
AF-Q9VEZ5-F1 Predicted AlphaFoldDB

No variants for Q9VEZ5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VEZ5

No associated diseases with Q9VEZ5

1 regional properties for Q9VEZ5

Type Name Position InterPro Accession
domain Interleukin-17 receptor C/E, N-terminal 55 - 292 IPR027841

Functions

Description
EC Number 2.7.11.10 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding Binding to an identical protein or proteins.
IkappaB kinase activity Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

12 GO annotations of biological process

Name Definition
antibacterial humoral response An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.
cellular response to hypoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
peptidoglycan recognition protein signaling pathway The series of molecular signals initiated by binding of peptidoglycan to a receptor and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of antibacterial peptide biosynthetic process Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis.
positive regulation of defense response to virus by host Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
positive regulation of DNA-binding transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
positive regulation of NIK/NF-kappaB signaling Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
regulation of innate immune response Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q14164 IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon Homo sapiens (Human) PR
O14920 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta Homo sapiens (Human) PR
Q9R0T8 Ikbke Inhibitor of nuclear factor kappa-B kinase subunit epsilon Mus musculus (Mouse) PR
10 20 30 40 50 60
MITVVFCFSD CHGGIQILGR MSSVNKIKLN ENNKMHSFGN WERCRNLGEG GFGLVIHWRN
70 80 90 100 110 120
RTTGREIATK HIKEMGALSA DQQVKLSERW NKELNWSRQF KNFPHIVAGV DIEDPDFLEY
130 140 150 160 170 180
LNGMFSAKLP VIVLEYCNGG DVRKRLQSPE NANGLTEFEV RQILGALRKA LHFLHSQCGI
190 200 210 220 230 240
CHRDLKPDNI VIQRGVDGKK IYKLTDFGLA RGTPDQTMVQ SVVGTRHYYA PEVVENGFYN
250 260 270 280 290 300
STVDLWSFGV IAYELVTGEL PFIPHQTLKN IILNLIKKPA KCIAITEDPE DNTRFVNQFE
310 320 330 340 350 360
LPQTHHLSRP WAAQFTKWLA SPLNSNYKER GQLAANNVPV VFADLDKILN MNVLTIFAVN
370 380 390 400 410 420
NCERLEYAVS AEMTMKDLIA LIVLDTGMDE KELYFVLPTS HPHKTITPKS TPLQLYVEEW
430 440 450 460 470 480
SDTSKDSRKW TKRSNPPVML YIFQVKKECD YKIPEPILSI LSRKFIANKF KTKERWLQKR
490 500 510 520 530 540
VVLDMLYVLT KEQARYEMLV SGINERALSL EDEMMENSFI DSIDKQRIII SFAYDQLTSL
550 560 570 580 590 600
LKEAQAKIPS RQLISSAQWE KLNRNYNFII QSAKSIRSFL EACLREAKDM VKTTNQLRKE
610 620 630 640 650 660
VCEKDLFDCA RFYKKYLCNG AIISPSELNN DAEEFAKSRF KLYNEGEARH LPKSIDHMHY
670 680 690 700 710 720
LYFKTKESIP VLLQQFCDIK KEIFQINLQM LMSASSTPPP KLELSAAMDR LAISSGSPSS
730 740 750
DPFDSLRTIN AIEEAERINN ILVNEMKIDH Y