Q9VE46

PR
Gene name
ChT
Protein name
High-affinity choline transporter 1
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG7708
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

484-614 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VE46

Entry ID Method Resolution Chain Position Source
AF-Q9VE46-F1 Predicted AlphaFoldDB

No variants for Q9VE46

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VE46

No associated diseases with Q9VE46

No regional properties for Q9VE46

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9VE46

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
amino acid transmembrane transporter activity Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.
choline transmembrane transporter activity Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
choline:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in).

3 GO annotations of biological process

Name Definition
acetylcholine biosynthetic process The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline.
amino acid transmembrane transport The process in which an amino acid is transported across a membrane.
choline transport The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MINIAGVVSI VLFYLLILVV GIWAGRKKQS GNDSEEEVML AGRSIGLFVG IFTMTATWVG
70 80 90 100 110 120
GGYINGTAEA IYTSGLVWCQ APFGYALSLV FGGIFFANPM RKQGYITMLD PLQDSFGERM
130 140 150 160 170 180
GGLLFLPALC GEVFWAAGIL AALGATLSVI IDMDHRTSVI LSSCIAIFYT LFGGLYSVAY
190 200 210 220 230 240
TDVIQLFCIF IGLWMCIPFA WSNEHVGSLS DLEVDWIGHV EPKKHWLYID YGLLLVFGGI
250 260 270 280 290 300
PWQVYFQRVL SSKTAGRAQL LSYVAAAGCI LMAIPPVLIG AIAKATPWNE TDYKGPYPLT
310 320 330 340 350 360
VDETSMILPM VLQYLTPDFV SFFGLGAVSA AVMSSADSSV LSAASMFARN VYKLIFRQKA
370 380 390 400 410 420
SEMEIIWVMR VAIIVVGILA TIMALTIPSI YGLWSMCSDL VYVILFPQLL MVVHFKKHCN
430 440 450 460 470 480
TYGSLSAYIV ALAIRLSGGE AILGLAPLIK YPGYDEETKE QMFPFRTMAM LLSLVTLISV
490 500 510 520 530 540
SWWTKMMFES GKLPPSYDYF RCVVNIPEDV QRVGDPSESG EQLSVMAGPL ARSYGAATMA
550 560 570 580 590 600
GKDERNGRIN PALESDDDLP VAEARRINQE TAQAQVKKML DNATGVKPSG GGGGHLQSQS
610
GMAMPTAEQD NTAF