Q9V785

PR
Gene name
pcs (CG7761)
Protein name
SH3 domain-binding protein 5 homolog
Names
Protein parcase
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG7761
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

33-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9V785

Entry ID Method Resolution Chain Position Source
AF-Q9V785-F1 Predicted AlphaFoldDB

No variants for Q9V785

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9V785

No associated diseases with Q9V785

No regional properties for Q9V785

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9V785

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
protein kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.
SH3 domain binding Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

8 GO annotations of biological process

Name Definition
anterior/posterior pattern specification The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
female germline ring canal formation Assembly of the intercellular bridges that connect the germ-line cells of a female cyst.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
mesoderm development The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
muscle cell fate specification The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
muscle organ development The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
muscle organ morphogenesis The process in which the anatomical structures of muscle are generated and organized.
negative regulation of protein tyrosine kinase activity Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7L8J4 SH3BP5L SH3 domain-binding protein 5-like Homo sapiens (Human) PR
10 20 30 40 50 60
MSSAEDGELD PQIQIELENL NSATDEINKL EIELEEANST FRILLNESTR RLKVSSKKLG
70 80 90 100 110 120
NCIEKARPYY EALDKAREAQ IECQKAAVKF QRANEIHAAA KETVALAEQR FMSNSHEWQF
130 140 150 160 170 180
DNAWQEMLNH ATQKVMDAET QKADCHAEHQ RLTKLFNAAE QKLQQLEDRF RRSINKSRPY
190 200 210 220 230 240
FEEKQVCQDQ LQTQKNRIQE LQQQVAGAKS TYSTALRNLE RISEDIHRQR GDFPTPPGPR
250 260 270 280 290 300
EPGVGAELNS PTSSALPSLP DFQLELEKCD YPSIAGSQMS LGAKTPQAAA ETEDEEDACD
310 320 330 340 350 360
YDETGAGELR GVVDERDLEA LRQKVKILAV RPIEGGDGQQ QNDVWEHELK ATVDKLDHLM
370 380 390 400 410 420
MLKETAKRQQ TNRLKSTEQR PDSLGAEALK RHCDVVEVKV TSCATTASLP VTPHHQLNHL
430 440 450 460 470
APPTPIKKLQ QQLAPLPSVN VSMRELPLLA RLSNELLDRS SAAFGGVRKT LRRRSLE