Q9V6G5
Gene name |
Taz |
Protein name |
Tafazzin |
Names |
TAZ, dTAZ |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG8766 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9V6G5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9V6G5-F1 | Predicted | AlphaFoldDB |
No variants for Q9V6G5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9V6G5 | |||||
No associated diseases with Q9V6G5
1 regional properties for Q9V6G5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phospholipid/glycerol acyltransferase | 162 - 306 | IPR002123 |
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrial membrane | Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-acylglycerophosphocholine O-acyltransferase activity | Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA. |
| acyltransferase activity | Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). |
| O-acyltransferase activity | Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. |
| phosphatidylcholine:cardiolipin O-linoleoyltransferase activity | Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cardiolipin acyl-chain remodeling | Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids. |
| cardiolipin biosynthetic process | The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. |
| cardiolipin metabolic process | The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. |
| inner mitochondrial membrane organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane. |
| mitochondrial membrane organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. |
| phospholipid metabolic process | The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
| sperm individualization | The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFMVVCSNLR | RPGHVGAASA | ARNINWLISE | GYTPPIRAMA | RPYVQAPEAR | PVPDERYPGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QQDRKDIATQ | TVRSSKPKDL | RPPSPPTPSQ | TLNSSSLPPP | MSDQDADPSL | DVPTGVAMPY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NIDWIFPRLR | NPSKFWYVVS | QFVVSAVGIF | SKVVLMFLNK | PRVYNRERLI | QLITKRPKGI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PLVTVSNHYS | CFDDPGLWGC | LPLGIVCNTY | KIRWSMAAHD | ICFTNKLHSL | FFMFGKCIPV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VRGIGVYQDA | INLCIEKAAL | GHWIHVFPEG | KVNMDKEELR | LKWGVGRIIY | ESPKIPIILP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MWHEGMDDLL | PNVEPYVIQR | GKQVTLNVGQ | PLDLNDFILD | LKKRQVPEPT | ARKLITDKIQ |
| 370 | |||||
| EAFRDLRAET | EKLHRERN |