Q9V2H1
Gene name |
cca |
Protein name |
CCA-adding enzyme |
Names |
CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT |
Species |
Pyrococcus abyssi (strain GE5 / Orsay) |
KEGG Pathway |
pab:PAB0063 |
EC number |
2.7.7.72: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9V2H1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9V2H1-F1 | Predicted | AlphaFoldDB |
No variants for Q9V2H1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9V2H1 | |||||
No associated diseases with Q9V2H1
2 regional properties for Q9V2H1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ResB-like domain | 14 - 277 | IPR007816-1 |
| domain | ResB-like domain | 345 - 419 | IPR007816-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.72 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity | Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate. |
| CTP:3'-cytidine-tRNA cytidylyltransferase activity | Catalysis of the reaction: a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate. |
| CTP:tRNA cytidylyltransferase activity | Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| tRNA binding | Binding to a transfer RNA. |
| tRNA cytidylyltransferase activity | Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| RNA repair | Any process that results in the repair of damaged RNA. |
| tRNA 3'-terminal CCA addition | Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLKMTLKEVL | ESIKPKDEER | KKVKLIMDEL | RGIAQEVIEE | SGEEIEVKFV | GSLAKDTYLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GDHDIDMFLA | FPLSIPVEKL | KSKGLEIAES | IGKRLESYEI | SYAEHPYVRG | VYKGYQVDIV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PCYNVRDWRE | VRTAVDRSIL | HTEWVLKNIK | GKNDEVRLLK | RFLKGINAYG | SEVYRRGFSG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YLAEILVIKF | GSFLKVLEKA | DFMLRQKIID | PENWLKREPE | IAMKTVKREI | EEDKPIIVID |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PVDPRRNVAA | NLSWERYGLF | YFKAREFLTK | PSTELFFPRD | KKGNYLEVLR | RKGTHLVTLT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FEPPNLVDDI | IIPQVERTAK | GLARQLELEG | FRVLGIDYGR | DFIFLEVEEI | ERPRIKIKKG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PLYFTHHGLR | FFDKNDIVWI | EGKELASEKS | SLGFIVDVLE | DILRKGQFSA | GKNVKDAIVG |
| 430 | 440 | ||||
| ANIIIDFVPK | ALAQEAYLFL | SREKFRVK |