Q9V1S2

PR
Gene name
pyrG
Protein name
CTP synthase
Names
Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase
Species
Pyrococcus abyssi (strain GE5 / Orsay)
KEGG Pathway
pab:PAB0231
EC number
6.3.4.2: Other carbon--nitrogen ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

161-243 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9V1S2

Entry ID Method Resolution Chain Position Source
AF-Q9V1S2-F1 Predicted AlphaFoldDB

No variants for Q9V1S2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9V1S2

No associated diseases with Q9V1S2

3 regional properties for Q9V1S2

Type Name Position InterPro Accession
domain CTP synthase, N-terminal 3 - 265 IPR017456
domain Glutamine amidotransferase 300 - 525 IPR017926
domain CTP synthase GATase domain 289 - 523 IPR033828

Functions

Description
EC Number 6.3.4.2 Other carbon--nitrogen ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
CTP synthase activity Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate.
glutaminase activity Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
'de novo' CTP biosynthetic process The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components.
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTKFIFVTGG VVSGLGKGIT SASIGLLMKA RGYKTTNIKI DPYINYDAGT MNPYQHGEVF
70 80 90 100 110 120
VLDDGGEVDL DLGNYERFLD TSLTFDHNIT TGKVYSTVIE KERRGEYLGA TVQVIPHITD
130 140 150 160 170 180
EIKRRIREIA RNYDIVVVEI GGTVGDIESM PFLEAARQMQ LEEGRENVAF VHVTYVPKLR
190 200 210 220 230 240
VVGEQKTKPT QHSVKELRSL GIQPDAIVAR SEDPLEEGAR KKISLFTNVP EEAVISAYDV
250 260 270 280 290 300
EDTYEVPLLL EREGLGKYLV KRLGLEDREP DLREWEKMVA KYKALQDSVE IAIVGKYVKL
310 320 330 340 350 360
TDSYLSIKEA LKHASVSNEV KVKIRWIEAE DIEEHGTKLL EGVDGIIVPG GFGARGAEGK
370 380 390 400 410 420
IMTIRYAREN DIPFLGICFG FQLTVVEFAR NVLGMKGAHS TEIDPQTPYP VVDLMPEQRN
430 440 450 460 470 480
LDKLGGTMRL GAYPVKIKKG TLAYELYKKD LVYERHRHRW EVNPDYIEAF EKAGLVFSGI
490 500 510 520 530
AGDDERRMEI LELPDKRYFI ATQFHPEFKS RPMKPAPVFH GLVKAAKEYK QEKDATH