Q9V072

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Pyrococcus abyssi (strain GE5 / Orsay)
KEGG Pathway
pab:PAB0616
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9V072

Entry ID Method Resolution Chain Position Source
AF-Q9V072-F1 Predicted AlphaFoldDB

No variants for Q9V072

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9V072

No associated diseases with Q9V072

4 regional properties for Q9V072

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 49 - 60 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 20 - 663 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 711 - 862 IPR013155
domain Isoleucyl tRNA synthetase type 2, anticodon-binding domain 664 - 845 IPR033709

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIKEPEFREY DPKKLEEKVE KFWSENEIYR KVKELRKDGP KYYFLDGPPY VSGAIHLGTA
70 80 90 100 110 120
WNKIIKDMII RFRTMQGYNV WRQPGYDMHG LPIEVKVEQA LGLKTKKEIE EKIGVENFIK
130 140 150 160 170 180
KCKEFALNNL KIMTEQFKML GIWMDWDNPY MTIKNEYIES AWFTLKRAWE KGLLEKDKRV
190 200 210 220 230 240
LHWCPRCETA LAEHEVRGEY KLRKDPSIYV KFPVEGKENE YLLIWTTTPW TLPANLAVSA
250 260 270 280 290 300
HPDYDYVKVK VEFNGREEYW ILAKALVDKV LGEIGVKGEV VEEFKGRELE GLRYVHILMD
310 320 330 340 350 360
EYPRQKEFKE KYEWAHRVIL ADFVTLEEGT GLVHTAPGHG EEDFEVGQKY GLPVYSPLDD
370 380 390 400 410 420
QGKYTEGKWK GIYVKEADPK IIEHLREKGY LVKAGEIEHK YPHCWRCKTP LIFRATDQWF
430 440 450 460 470 480
LKISKVKDKI IKENDEKVTW YPDWVKIRFD NGVRDSGDWV ISRQRYWGIP LPIWQSEDGE
490 500 510 520 530 540
IYVVGSWREL VELAVAIEVN GERIELPESY EEKLKVIEEK LGPEDLHRPY VDAFIIKVNG
550 560 570 580 590 600
KDMRRVKDVV DVWFDSGIAS WASLGYPRNK ELFEKLWPAD FIVEGEDQVT KWFYSQQAAS
610 620 630 640 650 660
IVAFDTVPYR RVAMHGYVLD EKGDKMSKSL GNIIRPEEVV ERAGRDTFRF YMLWATNPWE
670 680 690 700 710 720
NLKFSWKGVE QVRRMLNILW NVYVLASTYM SLDNFDPRKL NPDELPFREE DKWILSRVNS
730 740 750 760 770 780
LISEVENGIE SFYLTKATRA LYNFVVEDLS RWYVRLIRKR LWVEGEDPDK LAAYYTLWKV
790 800 810 820 830 840
FDVLLRLLAP FTPYIAEEIY QNLIRPFTNV ESVHMLDWPK VDEKAIDEEL EREMEFIRRI
850 860 870 880 890 900
VEAGSAARQR AKIKLRYPVR RIIIETEDET VKKAVERLNR ILRDQLNAKE VKVGRVEREL
910 920 930 940 950 960
TIKPNFAKLG PEFKGDAKII AKWINENGRE LYEKGELTVE IDGKTFHLTR EHIIVEEKLP
970 980 990 1000 1010 1020
DFFVSEEFEG GRVFVDKTLT RELIAEGLAR EFVRRIQEMR KRLDLDVNDR IIVTIETTDE
1030 1040 1050 1060
NVELLKENLD YIMRETRADK IVFGKAKGYV VEWPEVQAKI GIEKVEE