Q9UZK7

PR
Gene name
infB (PYRAB11390, PAB0755)
Protein name
Probable translation initiation factor IF-2
Names
Species
Pyrococcus abyssi (strain GE5 / Orsay)
KEGG Pathway
pab:PAB0755
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

693-770 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for Q9UZK7

Entry ID Method Resolution Chain Position Source
7YYP X-ray 290 A A 414-992 PDB
7YZN X-ray 170 A A 414-852 PDB
7ZAG EM 277 A 7 414-992 PDB
7ZAH EM 270 A 7 414-992 PDB
7ZKI EM 360 A 7 418-992 PDB
AF-Q9UZK7-F1 Predicted AlphaFoldDB

No variants for Q9UZK7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9UZK7

No associated diseases with Q9UZK7

5 regional properties for Q9UZK7

Type Name Position InterPro Accession
domain Translational (tr)-type GTP-binding domain 115 - 283 IPR000795
domain Small GTP-binding protein domain 120 - 270 IPR005225
domain Translation initiation factor IF-2, N-terminal 38 - 86 IPR006847
domain Translation initiation factor IF- 2, domain 3 392 - 501 IPR023115
domain Translation initiation factor IF-2, domain II 290 - 385 IPR044145

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

2 GO annotations of biological process

Name Definition
intein-mediated protein splicing The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues.
intron homing Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTKRIRQPII AVLGHVDHGK CLLPDEKVVV PSVGFVTLKE LFETASKVVE RDDEKEIREL
70 80 90 100 110 120
DERITSVNGD GKTGLVKASY VWKVRHKGKV IRVKLKNWHG VTVTPEHPFL TTKGWKRADQ
130 140 150 160 170 180
LRPGDYVAVP RFIHGNEDEK IFLSYVKVKK SGEEWKEYFY LAGRKGNIDV NLLFVAPKRY
190 200 210 220 230 240
VVEFLRGYFE ERSEVKGESV IVEARELVEP LSLALLRFGI FSKIQGSKLI VTGKRNLEAF
250 260 270 280 290 300
KDYIGFKDER EKALEEAIEK VKGSEVYPIF EEIRRLRLLF GFTREELGSY AKYENSEAPT
310 320 330 340 350 360
YEELMEILDF IERGSPSLSK KIAILEGKLK AELRVLEEEG LIKDGKLTPL GRELLEVWRN
370 380 390 400 410 420
REFDSKDVDY IRNIAETLVF IPVENVEEEE YDGYVYDLTT ETHNFIANGI LVHNTTLLDR
430 440 450 460 470 480
IRKTNVAAKE AGGITQHIGA TEVPIEVVKK IAGPLIKLWK AEIKLPGLLF IDTPGHEAFT
490 500 510 520 530 540
SLRARGGSLA DLAVLVVDIN EGFQPQTIES IEILRKYRTP FVVAANKIDR IKGWVIEEDE
550 560 570 580 590 600
PFLMNIKKQD QRAVQELETK LWELIGKFYE FGFQANRFDR VQNFTRELAI VPISAKYGIG
610 620 630 640 650 660
IAELLVLIAG LSQRYLEEKL KIEVEGPARG TILEVREEPG LGHTIDVIIY DGTLHKDDTI
670 680 690 700 710 720
VVGGKDKAIV TKIRALLKPK PLDEIRDPRF RFDYVDEVTA AAGVKIAAPG LEEALAGSPV
730 740 750 760 770 780
IAAPTPEDVE KAKQEILEQI ERVVISTDKV GVIVKADTLG SLEALSKELQ EKEIPIRKAD
790 800 810 820 830 840
VGNVSKTDVM EALSVKEEEP KYGVILGFNV KVNEDAEEVA KAKDVKIFVG NVIYKLIEDY
850 860 870 880 890 900
EEWVKEEEEK KKRELLSKVT FPGVIRLYPD ERYVFRRSNP AIVGIEVIEG RIKPGVTLIK
910 920 930 940 950 960
QNGQKVGVIR SIKSRDEFLQ EAKKGQAVAI AIEGAIVGRH IHPGETLYVD LSRDDAITLL
970 980 990
KHLRDTLEDT DIKALKMIAK VKAKEDPFWR AI