Q9UZC9

PR
Gene name
mre11
Protein name
DNA double-strand break repair protein Mre11
Names
Species
Pyrococcus abyssi (strain GE5 / Orsay)
KEGG Pathway
pab:PAB0811
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

354-415 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9UZC9

Entry ID Method Resolution Chain Position Source
AF-Q9UZC9-F1 Predicted AlphaFoldDB

No variants for Q9UZC9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9UZC9

No associated diseases with Q9UZC9

2 regional properties for Q9UZC9

Type Name Position InterPro Accession
domain Calcineurin-like phosphoesterase domain, ApaH type 4 - 210 IPR004843
domain Mre11 nuclease, N-terminal metallophosphatase domain 4 - 234 IPR041796

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA end binding Binding to DNA ends exposed by the creation of double-strand breaks (DSBs).
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
manganese ion binding Binding to a manganese ion (Mn).
Y-form DNA binding Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end.

1 GO annotations of biological process

Name Definition
double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGIKFAHLAD VHLGYEQFNR SQRAEEFAKA FEDAIKICVD EKVDFIVIAG DLFNSSRPSP
70 80 90 100 110 120
GTIKTAVKIL QIPRDNNIPV FAIEGNHDRT QRGPSILHLL EDLGLLYVLG VRDEKVENEY
130 140 150 160 170 180
LTSEKTKAGW LVKGMYKDVE IHGMKYMSAA WFEGNIELFK SMFRPEGDAI LVLHQGVREI
190 200 210 220 230 240
TENNYPNYSS ELSLSDLPKG YLYYALGHIH KRFELTYDDA PVVYPGSLER WDFGDYSLKL
250 260 270 280 290 300
TWNGFQFKEE VGVDKGFYIV EDFKPRFIRI NARDFIDVHI KGHSENEIKK AVKLAVPKIP
310 320 330 340 350 360
RNSYVRFNIR WKRPVDVDWI KSIVNAEYVR VNPIIIKEER GPDGKDLDVK KFFTELEWKI
370 380 390 400 410
IELASEKEYE YYLNQIIDLL ASEEGKVEAK IDAKREEKKF VRPKNPGDIM AWVKG