Q9UZ99

PR
Gene name
purB (PYRAB12550, PAB0829)
Protein name
Adenylosuccinate lyase
Names
ASL, Adenylosuccinase, ASase
Species
Pyrococcus abyssi (strain GE5 / Orsay)
KEGG Pathway
pab:PAB0829
EC number
4.3.2.2: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

232-314 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9UZ99

Entry ID Method Resolution Chain Position Source
AF-Q9UZ99-F1 Predicted AlphaFoldDB

No variants for Q9UZ99

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9UZ99

No associated diseases with Q9UZ99

3 regional properties for Q9UZ99

Type Name Position InterPro Accession
domain Adenylosuccinate lyase C-terminal 360 - 439 IPR019468
conserved_site Fumarate lyase, conserved site 272 - 281 IPR020557
domain Fumarate lyase, N-terminal 13 - 292 IPR022761

Functions

Description
EC Number 4.3.2.2 Lyases acting on amides, amidines, etc
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.

2 GO annotations of biological process

Name Definition
'de novo' AMP biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVHPIDYRY GSEEMRRVWE EENKLQKLLD VEAALARAHA KLGNIPEESA RVISERANTK
70 80 90 100 110 120
WVKLERVKEI EAEIHHDIMA VVKALSEVCG EHGKYVHLGA TSNDIIDTAN ALLIKESLAI
130 140 150 160 170 180
VEKDLKELRS ILKELAKKHI DTVCIGRTHG QHAVPTTYGM KFALWLDEIQ RHIERLQQLK
190 200 210 220 230 240
DRVLVGKMRG AVGTAASFGD KAFEIEKLVM EDLGLKPARI TNQIIQRDVY AELMFFLALV
250 260 270 280 290 300
ASTLDKMALE IRNLQRTEIL EVSEPFGEKQ VGSSTMPHKR NPIRTEKVCG LARVLYSNVI
310 320 330 340 350 360
PALLNNPLWH ERDLTNSSVE RVILPESFVL LDEMLKVMKK VLKGLEFFPE NIKRNLYLTK
370 380 390 400 410 420
NLIMAEPLML KLAEKGMGRQ EAHELVRQLA MKAFKEGRDL LEVVRKNEEA MKYLTENDLE
430 440
GLKPENYIGK AREIVENVVN YVEEMERRGL