Q9UZ14

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Pyrococcus abyssi (strain GE5 / Orsay)
KEGG Pathway
pab:PAB1490
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

18 structures for Q9UZ14

Entry ID Method Resolution Chain Position Source
1Y2Q X-ray 195 A A 1-143 PDB
2HKZ X-ray 210 A A 1-143 PDB
2HL0 X-ray 186 A A 1-143 PDB
2HL1 X-ray 225 A A/B 1-147 PDB
2HL2 X-ray 260 A A/B 1-143 PDB
3PD2 X-ray 186 A A/B 1-147 PDB
3PD3 X-ray 186 A A/B 1-147 PDB
3PD4 X-ray 240 A A/B 1-147 PDB
3PD5 X-ray 229 A A/B 1-147 PDB
4RRQ X-ray 179 A A/B 1-147 PDB
4RRR X-ray 186 A A/B 1-147 PDB
4S02 X-ray 195 A A 1-143 PDB
4S03 X-ray 205 A A 1-143 PDB
4S0I X-ray 236 A A 1-143 PDB
4S0J X-ray 210 A A 1-143 PDB
4S0K X-ray 210 A A 1-143 PDB
4S0L X-ray 250 A A 1-143 PDB
AF-Q9UZ14-F1 Predicted AlphaFoldDB

No variants for Q9UZ14

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9UZ14

No associated diseases with Q9UZ14

6 regional properties for Q9UZ14

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 288 - 491 IPR002314
domain Anticodon-binding 512 - 602 IPR004154
domain Aminoacyl-tRNA synthetase, class II 209 - 505 IPR006195
domain Threonyl-tRNA synthetase, editing domain, archaea 1 - 139 IPR015011
domain Threonine-tRNA ligase catalytic core domain 206 - 510 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 510 - 600 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRVLLIHSDY IEYEVKDKAL KNPEPISEDM KRGRMEEVLV AFISVEKVDE KNPEEVSLKA
70 80 90 100 110 120
IEEISKVAEQ VKAENVFVYP FAHLSSELAK PSVAMDILNR VYQGLKERGF NVGKAPFGYY
130 140 150 160 170 180
KAFKISCKGH PLAELSRTIV PEEARVEEVP EALRKEEEEL VSYWYILTPE GELIEVDKFD
190 200 210 220 230 240
FTGYENLRKF VNYEIAKNRI AEKEPPHVKL MLEHELVDYE PGSDPGNLRY YPKGRLIKSL
250 260 270 280 290 300
LEQYVTEKVI EYGAMEVETP IMYDFEHPAL EKYLNRFPAR QYIVLSGDKR YFLRFAACFG
310 320 330 340 350 360
QFMIKKDAII SYRNLPLRMY ELTRYSFRRE KRGELSGLRR LRAFTMPDMH TLAKDIEQAK
370 380 390 400 410 420
EEFKKQFKLS MEVLEGVGLT PEDYEVAIRF TEDFWKEHKD FIVELVKLIG KPVLIEMWKQ
430 440 450 460 470 480
RFFYFILKFE FNFVDNLDKA AALSTVQIDV ENAERFGITY YDENGEEKYP LILHCSPSGA
490 500 510 520 530 540
IERVMYAILE KQAKLMNEGK KPMFPLWLSP IQVRVIPVSE EYLDYALYVA GKLEGAKIRV
550 560 570 580 590 600
DVDDEDERLN KKIRRAEKEW IPYIVVVGAR EKENGTITVR RREDGKQYET RIEELIKEIK
610 620
EKTEGFPYKP RPLPLLLSKR PKFRG