Q9UYS8

PR
Gene name
topA
Protein name
DNA topoisomerase 1
Names
DNA topoisomerase I, Omega-protein, Relaxing enzyme, Swivelase, Untwisting enzyme
Species
Pyrococcus abyssi (strain GE5 / Orsay)
KEGG Pathway
pab:PAB1430
EC number
5.6.2.1: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

226-309 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9UYS8

Entry ID Method Resolution Chain Position Source
AF-Q9UYS8-F1 Predicted AlphaFoldDB

No variants for Q9UYS8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9UYS8

No associated diseases with Q9UYS8

8 regional properties for Q9UYS8

Type Name Position InterPro Accession
domain DNA topoisomerase, type IA, domain 2 130 - 225 IPR003601
domain DNA topoisomerase, type IA, DNA-binding domain 270 - 526 IPR003602
domain TOPRIM domain 1 - 141 IPR006171
domain DNA topoisomerase, type IA, central 102 - 115 IPR013497-1
domain DNA topoisomerase, type IA, central 155 - 574 IPR013497-2
domain DNA topoisomerase, type IA, zn finger 608 - 646 IPR013498
active_site DNA topoisomerase, type IA, active site 307 - 321 IPR023406
domain DNA topoisomerase 3-like, TOPRIM domain 1 - 151 IPR034144

Functions

Description
EC Number 5.6.2.1 Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type I (single strand cut, ATP-independent) activity Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MILVIAEKPN VARKIAGALS ERRPIRKTIF GVPYYEVFRD GKKLIVASAV GHLYGLAPKQ
70 80 90 100 110 120
DFFGYPIFDI EWVPVYIAEK NKDYAKDYIK ALSVLAKRVK EFIVACDYDT EGEVIGYTAL
130 140 150 160 170 180
KYACGVDPSR AKRMKFSALT KRDLLNAWRN LEPTINFGMA NAGIARHVLD WYWGVNLSRA
190 200 210 220 230 240
LTHAIKRASG KWVVLSTGRV QGPTLKFLVE REREIQSFVP KPYWVIKLVI EKNGQKLVAN
250 260 270 280 290 300
YEKDKIWSEE EAKKIVTEVK KSKARVSNIE VKRQKRNPPV PFDLGTLQRE AYSAFGFSPK
310 320 330 340 350 360
KTLDIAQSLY EKGFTSYPRT ESQKLPKNLN FRLIIQNISR MPQYRPYAHL LLGMPELKPV
370 380 390 400 410 420
EGKKEDPAHP AIYPTGEIPG PGDLSKDEEK LYDMIVRRFL ALFMEPAVRE SVKVTILAGP
430 440 450 460 470 480
HKFMLSGART VKQGWLSVYG KYIKFDEVTL PEFFIGERVR VLQVRREKKK TKPPARYSPA
490 500 510 520 530 540
AVIKKMEDLG IGTKATRAQI LETLYQRGYI EGKKSIKVTP LGMKVIETLE KYVPEIISVE
550 560 570 580 590 600
LTREFERKMD LIMQGKLTKE EVIEEAKVKL TKILEEFKKR ELEIGLELAR IVVGDVKDEI
610 620 630 640 650 660
KEEKPIVVGK CPKCGGDLIV KYNKKTGKRF VGCSNWPKCD VTYPILQRGE IIPTNKTCCN
670 680
GAPVVIIRDK GRDIEICLDI KCKKW