Q9UY36

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Pyrococcus abyssi (strain GE5 / Orsay)
KEGG Pathway
pab:PAB1245
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

395-540 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9UY36

Entry ID Method Resolution Chain Position Source
AF-Q9UY36-F1 Predicted AlphaFoldDB

No variants for Q9UY36

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9UY36

No associated diseases with Q9UY36

4 regional properties for Q9UY36

Type Name Position InterPro Accession
domain DHHA1 domain 784 - 913 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 704 - 747 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 61 - 605 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 57 - 760 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEFIMKTRMF EEEGWIRKKC KVCGKPFWTL DPDRETCGDP PCDEYQFIGK PGIPKKYTLD
70 80 90 100 110 120
EMREKFLKFF EKHEVYPHGR VKRYPVLPRW RDDVLLVGAS IMDFQPWVIS GEADPPANPL
130 140 150 160 170 180
VISQPSIRFT DIDNVGITGR HFTIFEMMAH HAFNYPGKPI YWIDETVELA FEFFTKELKM
190 200 210 220 230 240
KPEDITFKEN PWAGGGNAGP AFEVLYRGLE VATLVFMQYK KAPENAPEDQ VVIIKGDRYV
250 260 270 280 290 300
PMETKVVDTG YGLERLVWMS QGTPTAYDAV LGYVVEPLKR MAGVEKIDER ILMENSRLAG
310 320 330 340 350 360
MFDIEDMGDL KLLRKKVAEK VGISVEELEK AIRPYELIYA IADHTKALTF MLADGVIPSN
370 380 390 400 410 420
VKAGYLARLL IRKSIRHLKE LGLEVPLSEI VALHIKELHK TFPEFKEMED VILEIIDLEE
430 440 450 460 470 480
KKYSETLKRG SDLVRREIAK LKKKGMSEIP LEKLITFYES HGLTPELVKE IAEKEGIKVH
490 500 510 520 530 540
VPDNFYSIVA KEAEKEKEEK EEEVVDFELV KDLPETRTLY YEDPFMKEFE ARVLRVIGDW
550 560 570 580 590 600
IVLDQTAFYP EGGGQPYDTG VLFVNGSEVK VTNVQKVGKV IVHKVENPGL FKEGMEVRGR
610 620 630 640 650 660
IDWDRRIQHM RHHTGTHVLM GALVRVLGKH VWQAGSQLTT DWARLDISHY KRISDEELRE
670 680 690 700 710 720
IERLANRIVM EDRKVTWEWL PRTEAEQRYG FRLYQGGVVP GRVIRVVKIE DWDVQACGGT
730 740 750 760 770 780
HLPSTGLVGP IKILRTERIQ DGVERIIFAC GEAAIKEWQK EREILKKASQ VLRVPPEKLP
790 800 810 820 830 840
ETAERFFNEW KEARKEVEKL KKELAKLLVY ELEAKVQKVK EYEFIGEIVE GSMDDLREAV
850 860 870 880 890 900
ERLKKPNRIV VLVSKEGYFA ISVGDNVNLN ANDLAKKLTS IAGGGGGGRK DVAQGRIKDV
910
SKAKEAIESI VKLL