Q9UW24

PR
Gene name
PIKA (CAALFM_C501760CA, CaO19.3199)
Protein name
Phosphatidylinositol 4-kinase PIK1a
Names
PI4-kinase, PtdIns-4-kinase
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C501760CA
EC number
2.7.1.67: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

163-372 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

826-848 (Activation loop from InterPro)

Target domain

658-955 (Catalytic domain of Type III Phosphoinositide 4-kinase beta)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9UW24

Entry ID Method Resolution Chain Position Source
AF-Q9UW24-F1 Predicted AlphaFoldDB

No variants for Q9UW24

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9UW24

No associated diseases with Q9UW24

3 regional properties for Q9UW24

Type Name Position InterPro Accession
domain Phosphatidylinositol 3-/4-kinase, catalytic domain 658 - 953 IPR000403
domain Phosphoinositide 3-kinase, accessory (PIK) domain 1 - 120 IPR001263
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 793 - 813 IPR018936

Functions

Description
EC Number 2.7.1.67 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
1-phosphatidylinositol 4-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphatidylinositol kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate.

6 GO annotations of biological process

Name Definition
filamentous growth of a population of unicellular organisms The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
Golgi to plasma membrane protein transport The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
single-species biofilm formation on inanimate substrate A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPVAPHELRD TIKSRDLGLF QCIDLLKQHN DNIGVHHQLV QKLYSYSYDE LEFFIPQFIQ
70 80 90 100 110 120
LLVNFETDSM ALEDFLLHYC NQFPHFSLIV FWYLQAFLFE LRNEPKSYSF QTVRKFINKL
130 140 150 160 170 180
QNILFNVETS FHIRGPEFRE NMQPALILCG SVASAFSSPL VNEYALPIVR SQGKQQKSFV
190 200 210 220 230 240
FKLASFQKSL TRNLTMKNQR LSADAITPVI SDDDSKVSNR IQESQRLKTK YSKKKISAAL
250 260 270 280 290 300
QLDDSENYTT DEEELGYVQT LSRPKIREMK YTEVEENLKI NTIIRSKKNR SKTTVNSISF
310 320 330 340 350 360
FSDTDQSASM EEYNRSAQSL PELVRTRSRL DLYSSESEAA LGTSRNSAEL IISKKKFMGS
370 380 390 400 410 420
EVKTRPYKEL LKILQVNYSK KETSFIMSLQ NISLRLSSVP KVARLSALRA ELSIINESIL
430 440 450 460 470 480
PSEIDIPQLL PVTSNKNKKF HKILKLNINE ACVLNSAERV PYLLLIEYLS DEIDFNPFSD
490 500 510 520 530 540
QNQKIINDCV RKPEVKPNDQ ISGDDDTSVV SSIQEEMFLD NNASENYNED GDLGEISLLH
550 560 570 580 590 600
SRSSSRDWAK STPGSPVARS SQEDEKFYGN VSSTTGGTIE SSVLADQMRI ASLMLQQLES
610 620 630 640 650 660
SGQSNTQQFV SIRNRIIESM ISLQDQFDFI DYETLKELKT DEQDAGKRKL ENDFKLAEDW
670 680 690 700 710 720
NEKKHRIRKS SIYGHLENWD LCSVIVKNGD DLPQEAFACQ LISLISNIWK KHKVDFWTKR
730 740 750 760 770 780
MKILITSANA GLVETITNAM SIHSIKKSLT ELSIENGENA KGRIFTLKDY FQKLYGSVDS
790 800 810 820 830 840
SKYVKAQENF AISLASYSII CYVLQIKDRH NGNIMLDHEG HIIHIDFGFL LSNSPGSVGF
850 860 870 880 890 900
EAAPFKLTSE YVEVLGGLES KAYLKFVDTC KNCFKALRKE WGQIVSIVEL MQKGSSLPCF
910 920 930 940 950
NNGDNTSVLL QQRLQLHLSD EEIDSFIEVY LIEKSVGSMY TRLYDQFQMI TQGIYS