Q9UUJ9

PR
Gene name
ach1 (SPAC1952.09c)
Protein name
Acetyl-CoA hydrolase
Names
Acetyl-CoA deacylase, Acetyl-CoA acylase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC1952.09c
EC number
3.1.2.1: Thiolester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9UUJ9

Entry ID Method Resolution Chain Position Source
AF-Q9UUJ9-F1 Predicted AlphaFoldDB

2 variants for Q9UUJ9

Variant ID(s) Position Change Description Diseaes Association Provenance
I_4982239_G_A 221 P>S No Jeffares_SNPs
I_4981432_C_T 490 A>T No Jeffares_SNPs

No associated diseases with Q9UUJ9

2 regional properties for Q9UUJ9

Type Name Position InterPro Accession
domain Acetyl-CoA hydrolase/transferase, N-terminal 11 - 229 IPR003702
domain Acetyl-CoA hydrolase/transferase C-terminal domain 330 - 480 IPR026888

Functions

Description
EC Number 3.1.2.1 Thiolester hydrolases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
acetate CoA-transferase activity Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.
acetyl-CoA hydrolase activity Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+).

4 GO annotations of biological process

Name Definition
acetate metabolic process The chemical reactions and pathways involving acetate, the anion of acetic acid.
acetyl-CoA metabolic process The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
propionate metabolic process, methylcitrate cycle The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSLLSSRIR NAEFAKKIVT DPAKLVPYFK NGDYVGWSGF TGVGYPKMIP NALARHVEEN
70 80 90 100 110 120
NLQGKLRFKL FVGASGGADT ECKWAELNMI ERRCPHQVGK PISKGINSGR IQFFDKHLSM
130 140 150 160 170 180
FPQDLLYGYY TRNRESNTID TAIIEATAIT EDGGIVPGAS VGASPELMQL AEKIIIEVNT
190 200 210 220 230 240
AIPSFEGLHD IVEIPNPPHR TPININRVDD RIGKPYIKVD PKKVIGIVEA DYGDITCANS
250 260 270 280 290 300
PQDETSQAIA GHLVDFFHHE VSVGRLPKNL HPLQSGIGNI ANAIIGGLAH SPFKDLEVWT
310 320 330 340 350 360
EVLQDTFLPL FDSEKLRFAT ATSTRFSPQG FEKFYSNYDY YKERILLRPQ VISNHPEIIR
370 380 390 400 410 420
RLGCIAMNTP VEADIYAHAN STNVLGSRML NGLGGSADFL RNAKLSIMHT PSVRPSKKDP
430 440 450 460 470 480
TGITCIVPMA THVDQTEHDL DILVTEQGLA DLRGLSPTER AREVIDKCAH PDYKPLLREY
490 500 510 520
FDIAENYCLA RGAGHEPHIL ANAFKMQLNL LEKGTMKIDH W