Q9UUE6

PR
Gene name
krs1 (SPBC17G9.03c)
Protein name
Lysine--tRNA ligase, cytoplasmic
Names
Lysyl-tRNA synthetase, LysRS
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC17G9.03c
EC number
6.1.1.6: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9UUE6

Entry ID Method Resolution Chain Position Source
AF-Q9UUE6-F1 Predicted AlphaFoldDB

No variants for Q9UUE6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9UUE6

No associated diseases with Q9UUE6

5 regional properties for Q9UUE6

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (D/K/N) 228 - 577 IPR004364
domain OB-fold nucleic acid binding domain, AA-tRNA synthetase-type 126 - 209 IPR004365
domain Aminoacyl-tRNA synthetase, class II 248 - 579 IPR006195
domain Lysyl-tRNA synthetase, class II, C-terminal 241 - 579 IPR018149
domain Lysine-tRNA ligase, class II, N-terminal 125 - 238 IPR044136

Functions

Description
EC Number 6.1.1.6 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).
tRNA binding Binding to a transfer RNA.

2 GO annotations of biological process

Name Definition
cytoplasmic translation The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEEQVNGVT QAVKALVLDP VTGEQVSKTE LKKREKQRAR ELAKAKKQAE KAASAPVAAP
70 80 90 100 110 120
KSSSKKEEDL DPSQYFENRS RTIMELRQTK DPNPYPHKFQ VTITLPEFIA KYEGLARGET
130 140 150 160 170 180
KPEVEVAVAG RVLGLRTAGN KLRFYEIHAD GKKLQVMCQA QDADTVDFAA QHEHLRRGDI
190 200 210 220 230 240
IGIRGYPGRS NPKGRADGEL SIFARQCVLL SPCLRMLPKE HYGLKDLEIR HRQRYLDLIM
250 260 270 280 290 300
NRSTRDRFVM RSRIIQYIRH FFDSRDFMEV ETPMMNMIAG GATAKPFVTH HNDLDMDLYM
310 320 330 340 350 360
RIAPELYLKM LVVGGLDRVY EIGRQFRNEG ADLTHNPEFT SIEFYQAYAD YYDLMDTTEE
370 380 390 400 410 420
LLSGLVKDLT GSYKVPYHPE GPEGPKWELD FSRPWRRINM IEYLEEKLNT KFPPGDQLHT
430 440 450 460 470 480
PEANAFLRDL CAKHGVECAP PQTCSRLLDK LVGEFIESEC INPTFIIGHP QMMSPLAKYH
490 500 510 520 530 540
RSDAGLCERF EAFVATKEIC NAYTELNDIF DQRARFEEQA RQKAQGDDEA QIIDENFCTA
550 560 570 580 590
LEYGLPPTGG WGMGVDRLVM FLTDSNTIRE VLLFPHMKPE VQAAEPTVVK E