Q9UUB6

PR
Gene name
uch2 (SPBC409.06)
Protein name
Ubiquitin carboxyl-terminal hydrolase 2
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC409.06
EC number
3.4.19.12: Omega peptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

201-279 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9UUB6

Entry ID Method Resolution Chain Position Source
AF-Q9UUB6-F1 Predicted AlphaFoldDB

No variants for Q9UUB6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9UUB6

No associated diseases with Q9UUB6

No regional properties for Q9UUB6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9UUB6

Functions

Description
EC Number 3.4.19.12 Omega peptidases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear periphery The portion of the nuclear lumen proximal to the inner nuclear membrane.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.

3 GO annotations of molecular function

Name Definition
cysteine-type deubiquitinase activity An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
deNEDDylase activity An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.
metal-dependent deubiquitinase activity An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.

3 GO annotations of biological process

Name Definition
cytoplasm protein quality control by the ubiquitin-proteasome system The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation.
protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein.
protein deubiquitination The removal of one or more ubiquitin groups from a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSWTTIESDA GVFTDLIENL GVKDVEVDEL YSLDVDSLRQ FPDIYGIIFL FKWNSKVDKP
70 80 90 100 110 120
DGTMDYDSMD NIFFAKQVIN NACATQALLS VLLNHSDEID LGTTLSEFKD FSKTLPPELK
130 140 150 160 170 180
GEALGNSEHI RCCHNSFARS DPFISEEVRA ATDEDEVYHF IAYTNINNVF YELDGLQAAP
190 200 210 220 230 240
INHGSCTKEE FAEKAVSVIQ ARIANYDPAE IRFNLMVICK DKKASLLTRE DLTDEEKAAS
250 260 270 280 290
IAVEDEKRLR WKRENQLRRH NFVGLFVELS KLLVKDRIDK NTWNSTLETA KAKYASQKRP