Q9UU94
Gene name |
epl1 (SPCC830.05c) |
Protein name |
Enhancer of polycomb-like protein 1 |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCC830.05c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9UU94
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9UU94-F1 | Predicted | AlphaFoldDB |
No variants for Q9UU94
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9UU94 | |||||
No associated diseases with Q9UU94
1 regional properties for Q9UU94
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Enhancer of polycomb-like, N-terminal | 12 - 159 | IPR019542 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| NuA4 histone acetyltransferase complex | A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Piccolo NuA4 histone acetyltransferase complex | A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSVSKNARA | YRQRKVGIKT | VMPIYFERDI | PDFDEEASLQ | RTVPLVESGV | EKEEEEEKHL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QQVINEAHEA | IVRGSEKKLI | IPTREAKNIG | IIDKYYKKNF | ILPKTLIRFS | LTVEECTNPE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YCMDEHDTEY | FLKLKQAQPS | LSKFSELDFE | IVMQTFEEEI | NQNQPFLSMD | TSQILPLSEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ITSFELKDVL | YLKPLASQVY | PYWRERRISK | GGLPIMAKAQ | VGDDKDDDDP | YVCFRRREIR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QARKTRRSDA | QSYDRLRRLR | QSMETSLQLL | EQVYKREQKK | LQALEDDYAI | FQKRCLVKKL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KRTLNIKDSD | ELLINPKRRP | IEVKPAAPVP | TPAPPVKTSP | HPASYRPQPT | RNVEVRPLLM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LDDVQSAQIT | QFQIRLQQRL | TKKEQLDRNW | VDLLETPSTV | IHTNYPDSFY | RNIIPYYSGK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ETKQSHNQLS | IPSSTPSTPL | SDNGPTYSTP | HSSLSNFNTC | DSLSFSSNNS | LYGYSTLLHP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RNPICVRQRI | GRGGRLMLDR | TRALPVHRLS | KPKSRVEDRW | LFDIPFDADD | TIILDDESDA |
| 550 | |||||
| SIMFRASLLN | DDMGTQS |