Q9UU76

PR
Gene name
puf6 (SPCP1E11.11)
Protein name
Pumilio homology domain family member 6
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCP1E11.11
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-181 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9UU76

Entry ID Method Resolution Chain Position Source
AF-Q9UU76-F1 Predicted AlphaFoldDB

No variants for Q9UU76

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9UU76

No associated diseases with Q9UU76

7 regional properties for Q9UU76

Type Name Position InterPro Accession
repeat Pumilio RNA-binding repeat 161 - 196 IPR001313-1
repeat Pumilio RNA-binding repeat 197 - 232 IPR001313-2
repeat Pumilio RNA-binding repeat 233 - 268 IPR001313-3
repeat Pumilio RNA-binding repeat 346 - 381 IPR001313-4
repeat Pumilio RNA-binding repeat 382 - 418 IPR001313-5
domain CPL domain 431 - 565 IPR012959
domain Pumilio homology domain 132 - 509 IPR033133

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
mRNA 3'-UTR binding Binding to a 3' untranslated region of an mRNA molecule.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
mRNA regulatory element binding translation repressor activity Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.

2 GO annotations of biological process

Name Definition
regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAIGKRKEST EVKKKDGSMN KRVKVAKLPK KVDSFSPKKK KNTTSSGSSE SDSMSQNDKK
70 80 90 100 110 120
KDSSLNESED EDFAGFGESA SENDELESAE SEAENDEESS SQKSNSKESH AQRKKLQKER
130 140 150 160 170 180
KAMKPFADTS LKAKSLWDKL RQKTSIKAEE RKTIIAELFD LIRTNVKQLV FKHDMSRVVQ
190 200 210 220 230 240
TCVKFGSKQQ RETICAELAG SYVDLCKSPY GKYLAIKIFK YGTPKMKEVI LGEMYGNVVK
250 260 270 280 290 300
MIRHREAAYV VEDAFREFTN LQQQRALICE FYGPEFQVFK DRTQDIHIDK LLIDHPEKRP
310 320 330 340 350 360
SIMQNLWKTI EGSIAKGSIG FTMVHRAMLE FINHADSNEA KELLNLTKEL IYEFVHTRDG
370 380 390 400 410 420
SQVAMKLFAL ANAKDRKVML KSLRPYLIET AKDSYGHLVV VAALDCTDDT IMTGKLLQAE
430 440 450 460 470 480
FEGELLKLSA DKFARRILLY VLVGWEDARY FSKENRELLR SLDSLKAKTS KKDPIVRRNE
490 500 510 520 530 540
LKATIGPLLI SLISKAAGDM IAESLASQVL VDALLYAPCE KEEAVDATLK AFDGNPEQDN
550 560 570 580 590 600
HLIHQIHCSR ALKTLVQNGH WSGAEKQVVK AEDDLKVASK LIVIIKKYLV EWASGDGAFV
610 620 630 640
VVAVLEALSD SEKQEFLKIL RKHKNQLNKS EFRGTKKLLE ML